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Dokumente

N5536

Sigma-Aldrich

Nefazodon -hydrochlorid

≥98% (HPLC), solid, antidepressant

Synonym(e):

2-{3-[4-(3-Chlorphenyl)-1-piperazinyl]-propyl}-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-on -hydrochlorid, BMY-13754, MJ-13754-1, Serzone

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About This Item

Empirische Formel (Hill-System):
C25H32ClN5O2 · HCl
CAS-Nummer:
82752-99-6
Molekulargewicht:
506.47
MDL-Nummer:
MFCD00935760
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24724551
NACRES:
NA.77

product name

Nefazodon -hydrochlorid, ≥98% (HPLC), solid

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

desiccated

Farbe

white

Löslichkeit

DMSO: ≥10 mg/mL
H2O: insoluble

Ersteller

Bristol-Myers Squibb

SMILES String

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.Cl

InChI

1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

InChIKey

DYCKFEBIOUQECE-UHFFFAOYSA-N

Angaben zum Gen

human ... HTR2A(3356) , HTR2C(3358) , SLC6A2(6530) , SLC6A4(6532)

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Biochem./physiol. Wirkung

Neuartiges Antidepressivum, gemischter 5-HT2A Serotonin-Rezeptor-Antagonist/Serotonin-Wiederaufnahme-Hemmer.

Leistungsmerkmale und Vorteile

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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S C Collins et al.
Diabetologia, 51(9), 1689-1693 (2008-07-16)
Long-term exposure to NEFAs leads to inhibition of glucose-induced insulin secretion. We tested whether the release of somatostatin and glucagon, the two other major islet hormones, is also affected. Mouse pancreatic islets were cultured for 72 h at 4.5 or
Jonathan N Bauman et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(6), 1016-1029 (2008-03-12)
In vitro metabolism/bioactivation of structurally related central nervous system agents nefazodone (hepatotoxin) and aripiprazole (nonhepatotoxin) were undertaken in human liver microsomes in an attempt to understand the differences in toxicological profile. NADPH-supplemented microsomal incubations of nefazodone and glutathione generated conjugates
James A Dykens et al.
Toxicological sciences : an official journal of the Society of Toxicology, 103(2), 335-345 (2008-03-18)
Mitochondrial toxicity is increasingly implicated in a host of drug-induced organ toxicities, including hepatotoxicity. Nefazodone was withdrawn from the U.S. market in 2004 due to hepatotoxicity. Accordingly, we evaluated nefazodone, another triazolopyridine trazodone, plus the azaspirodecanedione buspirone, for cytotoxicity and
James H Kocsis et al.
The Journal of clinical psychiatry, 70(3), 354-361 (2009-02-05)
Little is known about moderators of response to psychotherapy, medication, and combined treatment for chronic forms of major depressive disorder (MDD). We hypothesized that patient preference at baseline would interact with treatment group to differentially affect treatment outcome. We report
Niklaus Stulz et al.
Journal of consulting and clinical psychology, 78(3), 409-419 (2010-06-03)
Psychotherapy-pharmacotherapy combinations are frequently recommended for the treatment of chronic depressive disorders. Our aim in this novel reanalysis of archival data was to identify patient subgroups on the basis of symptom trajectories and examine the clinical significance of the resultant
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