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N4766

Sigma-Aldrich

N-Nitroso-N-methylurea

Bulk package

Synonym(e):

MNU, N-Methyl-N-nitrosourea

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About This Item

Empirische Formel (Hill-System):
C2H5N3O2
CAS-Nummer:
684-93-5
Molekulargewicht:
103.08
MDL-Nummer:
MFCD00014794
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24897712

Form

solid

Enthält

aqueous acetic acid as stabilizer

Lagertemp.

2-8°C

SMILES String

CN(N=O)C(N)=O

InChI

1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)

InChIKey

ZRKWMRDKSOPRRS-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.

Verpackung

Weight on dry basis.

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Carc. 1B - Flam. Sol. 2 - Repr. 1B

Lagerklassenschlüssel

4.1B - Flammable solid hazardous materials

WGK

WGK 1

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

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Marzena Kurowska et al.
Mutation research, 738-739, 52-70 (2012-10-23)
We present studies aimed at determining the types and frequencies of mutations induced in the barley genome after treatment with chemical (N-methyl-N-nitrosourea, MNU) and physical (gamma rays) mutagens. We created M(2) populations of a doubled haploid line and used them
Yuan-Yuan Chen et al.
Experimental eye research, 121, 102-113 (2014-02-11)
Mouse retinal degeneration models have been investigated for many years in the hope of understanding the mechanism of photoreceptor cell death. N -methyl- N -nitrosourea (MNU) has been previously shown to induce outer retinal degeneration in mice. After MNU was
Kawiya Sintara et al.
Journal of biomedicine & biotechnology, 2012, 915380-915380 (2012-06-13)
To determine effects of curcumin on N-methyl-N-nitrosourea (MNU) and saturated sodium chloride (s-NaCl)-induced gastric cancer in rats. Male Wistar rats were divided into 5 groups: control (CO), control supplemented with 200 mg/kg curcumin (CC), MNU + s-NaCl, MNU + s-NaCl supplemented with 200 mg/kg curcumin daily
Alice A Ramos et al.
Journal of toxicology and environmental health. Part A, 75(13-15), 765-775 (2012-07-14)
DNA damage induced by oxidative and alkylating agents contributes to carcinogenesis, leading to possible mutations if replication proceeds without proper repair. However, some alkylating agents are used in cancer therapy due to their ability to induce DNA damage and subsequently
Yong Soon Chun et al.
Carcinogenesis, 33(11), 2242-2249 (2012-07-27)
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible 'mega' doses for achieving detectable tissue levels.
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