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MAK110
MTP Activity Assay Kit
Supplied by Roar Biomedical, Inc.
Synonym(e):
MTTP Activity Assay Kit, Microsomal triglyceride transfer protein activity assay kit
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CHF 655.00
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About This Item
UNSPSC-Code:
12161503
NACRES:
NA.84
Empfohlene Produkte
Verwendung
sufficient for 100 fluorometric tests
Anwendung(en)
pharmaceutical
Nachweisverfahren
fluorometric
Relevante Krankheit(en)
cardiovascular diseases
Lagertemp.
2-8°C
Angaben zum Gen
human ... MTTP(4547)
Allgemeine Beschreibung
Microsomal triglyceride transfer protein (MTP), a membrane-bound protein present in the liver, plays an important role in the assembly and secretion of very low density lipoprotein (VLDL).[1] MTP is also necessary for assembly and secretion of chylomicrons by the intestine.[1] This protein facilitates the transfer of triglyceride (TG), cholesteryl ester (CE) and phosphatidylcholine (PC) between phospholipid surfaces. Mutation in the MTP gene leads to abetalipoproteinemia.[1][2]
Anwendung
MTP Activity Assay Kit has been used to measure the activity of microsomal triglyceride transfer protein (MTP).[3]
Leistungsmerkmale und Vorteile
Compatible with high-throughput handling systems.
Eignung
Suitable for measuring microsomal [triglyceride] transfer protein (MTP) activity in cell lysates or tissue homogenates, or for screening MTP activity inhibitors.
Prinzip
The MTP Activity Assay Kit is a sensitive, homogeneous fluorometric assay useful for continuous measurement of MTP activity in cell lysate or tissue homogenate. This kit includes proprietary substrates that enable the detection of MTP-mediated transfer of neutral lipid. The transfer activity results in an increase in fluorescence intensity (λEx=465 nm/λEm=535 nm).
Hinweis zur Analyse
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Lagerklassenschlüssel
10 - Combustible liquids
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Microsomal triglyceride transfer protein specificity of lipid binding and transport.
Jamil H, et al.
The Journal of Biological Chemistry, 270(12), 6549-6554 (1995)
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