M9066

Microsomes from Liver, Pooled

from rat(Sprague-Dawley), male

• Synonym(e): Liver microsome preparation
• UNSPSC-Code: 12161501
• NACRES: NA.47

Eigenschaften

• Biologische Quelle: rat (Sprague-Dawley)
• Qualitätsniveau: 200
• Form: liquid
• Verpackung: vial of ~10 mg
• Versandbedingung: dry ice
• Lagertemp.: −70°C

Beschreibung

Allgemeine Beschreibung

Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).[1]

Anwendung

Microsomes from Liver, Pooled has been used in following studies:

• inhibition of microsomal lipid peroxidation.[2]
• hydroxylation of isorhynchophylline (ISOR) in rats.[3]

Biochem./physiol. Wirkung

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Microsomes might act as cell organelles and are actively involved in protein synthesis.[1] Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids.[4] Murine liver microsomes plays a crucial role in degradation of small antimicrobial β^2,2-amino acid derivatives.[3]

Source of drug metabolizing enzymes, including cytochrome P-450.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable