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M3074

Sigma-Aldrich

MMPIP

≥98% (HPLC)

Synonym(e):

6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[ 4,5-c]pyridin-4(5H)-one

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About This Item

Empirische Formel (Hill-System):
C19H15N3O3
CAS-Nummer:
479077-02-6
Molekulargewicht:
333.34
MDL-Nummer:
MFCD12195836
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329817961
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to off-white

Löslichkeit

DMSO: ≥10 mg/mL

Ersteller

Merck & Co., Inc., Kenilworth, NJ, U.S.

Lagertemp.

room temp

SMILES String

COc1ccc(cc1)C2=Cc3onc(-c4ccncc4)c3C(=O)N2C

InChI

1S/C19H15N3O3/c1-22-15(12-3-5-14(24-2)6-4-12)11-16-17(19(22)23)18(21-25-16)13-7-9-20-10-8-13/h3-11H,1-2H3

InChIKey

PDWYBOZNEVALOV-UHFFFAOYSA-N

Biochem./physiol. Wirkung

MMPIP is a potent, selective, allosteric antagonist of metabotropic glutamate receptor 7 (mGluR7).
MMPIP is a potent, selective, allosteric antagonist of metabotropic glutamate receptor 7 (mGluR7). It also displays intrinsic activity and acts as an inverse agonist.

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number
100M4708

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Paulina Cieślik et al.
Frontiers in molecular neuroscience, 11, 316-316 (2018-10-09)
The data concerning antipsychotic-like activity of negative allosteric modulators (NAMs)/antagonists of mGlu7 receptors are limited. The only available ligands for this receptor are MMPIP and ADX71743. In the present studies, we used stable cell line expressing mGlu7 receptor and it
Juan Du et al.
Nature, 594(7864), 589-593 (2021-06-18)
The metabotropic glutamate receptors (mGlus) are involved in the modulation of synaptic transmission and neuronal excitability in the central nervous system1. These receptors probably exist as both homo- and heterodimers that have unique pharmacological and functional properties2-4. Here we report
Jolanta H Kotlinska et al.
European journal of pharmacology, 858, 172512-172512 (2019-07-02)
The present study was conducted to evaluate the influence of AMN082, the metabotropic glutamate receptor subtype 7 (mGlu7) allosteric agonist on different stages of memory processes connected with fear conditioning in the passive avoidance (PA) learning task in mice and
George A Lemieux et al.
PLoS biology, 11(11), e1001712-e1001712 (2013-11-22)
Phenotypic screens can identify molecules that are at once penetrant and active on the integrated circuitry of a whole cell or organism. These advantages are offset by the need to identify the targets underlying the phenotypes. Additionally, logistical considerations limit
Sinead E Shortall et al.
Molecular neurobiology, 57(8), 3439-3457 (2020-06-14)
Despite several compounds entering clinical trials for the negative and cognitive symptoms of schizophrenia, few have progressed beyond phase III. This is partly attributed to a need for improved preclinical models, to understand disease and enable predictive evaluation of novel
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