M2537

Mevastatin

≥98% (HPLC), powder or crystals

• Synonym(e): Compactin, ML-236B
• Empirische Formel (Hill-System): C₂₃H₃₄O₅
• CAS-Nummer: 73573-88-3
• Molekulargewicht: 390.51
• Beilstein: 1269441
• MDL-Nummer: MFCD05662341
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278540
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: powder or crystals
• Farbe: white to light yellow
• mp (Schmelzpunkt): 151 °C
• Löslichkeit: ethanol: 25-26 mg/mL, clear, colorless
• Wirkungsspektrum von Antibiotika: neoplastics
• Wirkungsweise: enzyme | inhibits
• Ersteller: Daiichi-Sankyo
• Lagertemp.: 2-8°C
• SMILES String: [H][C@]12[C@H](CCC=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)[C@@H](C)CC
• InChI: 1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
• InChIKey: AJLFOPYRIVGYMJ-INTXDZFKSA-N
• Angaben zum Gen: human ... HMGCL(3155) , HMGCR(3156) ; rat ... Hmgcr(25675)

Beschreibung

Allgemeine Beschreibung

Chemical structure: statin

Mevastatin is a polyketide that belongs to the class of statins. It contains a hydroxy-hexahydronaphthalene ring.[1]

Anwendung

Mevastatin has been used:

• to analyze its effects on chronic lymphocytic leukemia (CLL) cells by cytotoxic assay[2]
• as a prenylation inhibitor to analyze its effects on human embryonic kidney (HEK) cells transfected with K-Ras[3]
• as a statin agent to study its anti-cancer effect on human breast cancer cells and glioblastoma in vitro[4]

Biochem./physiol. Wirkung

Mevastatin is a selective inhibitor of 3-hydroxy 3-methyl glutaryl coenzyme(A) reductase (HMG-CoA reductase), a major enzyme involved in cholesterol synthesis. It acts as a cholesterol-lowering agent. Mevastatin is obtained from various species of fungi.[1] It acts as an antiresorptive agent and has therapeutic effects to treat osteoporosis. Mevastatin inhibits bone resorption by triggering osteoclast apoptosis. It is also involved in the inhibition of prenylation of proteins such as Ras.[5] Mevastatin increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels by blocking the geranylgeranylation of transcription factor Rho.[6]

Leistungsmerkmale und Vorteile

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)