M2319

Mefloquin -hydrochlorid

≥98% (HPLC), powder

• Synonym(e): (AS)-rel-a-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
• Empirische Formel (Hill-System): C₁₇H₁₇ClF₆N₂O
• CAS-Nummer: 51773-92-3
• Molekulargewicht: 414.77
• EG-Nummer: 257-412-0
• MDL-Nummer: MFCD00797519
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24724536
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white
• Löslichkeit: DMSO: soluble 38 mg/mL; H₂O: insoluble
• SMILES String: Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F
• InChI: 1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1
• InChIKey: WESWYMRNZNDGBX-YLCXCWDSSA-N

Beschreibung

Anwendung

Mefloquine hydrochloride has been used:

• to treat cochlear organotypic cultures with various doses to evaluate its role in cellular pathway involved in apoptosis[1]
• in screening for in vitro antischistosomal activity[2]
• in cytotoxicity assay of glioblastoma cells[3]

Biochem./physiol. Wirkung

Blocker of gap junction channels Cx36 and Cx50.

Mefloquine is broadly used as an antimalarial drug.[1] It inhibits 80S ribosomes of Plasmodium.[4] It has numerous side effects like anxiety, dizziness, tremor, headache, and hearing loss. Mefloquine damages cochlear and vestibular hair cells through apoptosis. It also damages spiral ganglion neurons, degenerates cortical neuron and disrupts neuronal calcium homeostasis.[1]

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves