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Merck

K8625

Sigma-Aldrich

L-Kynurenin

≥98% (HPLC)

Synonym(e):

β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

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25 MG
CHF 58.40
100 MG
CHF 197.00
500 MG
CHF 607.00
1 G
CHF 999.00

CHF 58.40


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25 MG
CHF 58.40
100 MG
CHF 197.00
500 MG
CHF 607.00
1 G
CHF 999.00

About This Item

Empirische Formel (Hill-System):
C10H12N2O3
CAS-Nummer:
Molekulargewicht:
208.21
MDL-Nummer:
UNSPSC-Code:
12352209
PubChem Substanz-ID:
NACRES:
NA.26

CHF 58.40


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Produktbezeichnung

L-Kynurenin, ≥98% (HPLC)

Assay

≥98% (HPLC)

Form

powder

mp (Schmelzpunkt)

219 °C

Anwendung(en)

detection

SMILES String

N[C@@H](CC(=O)c1ccccc1N)C(O)=O

InChI

1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1

InChIKey

YGPSJZOEDVAXAB-QMMMGPOBSA-N

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Anwendung

L-Kynurenine has been used as a standard for indoleamine-2,3-dioxygenase (IDO) assay.[1] It has also been used as a standard to extract and quantify kynurenine from cultured cells and media.[2]

Biochem./physiol. Wirkung

Key intermediate in the breakdown pathway of tryptophan.
L-Kynurenine is a key intermediate in the breakdown of L-tryptophan[3] and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. It is involved in a variety of neurological processes and diseases.[4][5] L-Kynurenine is a substrate for kynureninase/kynurenine hydrolase; kynurenine 3-monooxygenase and kynurenine-oxoglutarate transaminase.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Evaluation of radiofluorinated carboximidamides as potential IDO-targeted PET tracers for cancer imaging
Xuan Huang
Oncotarget, 8(29), 46900-46914 (2017)
Essential and Non-Essential Metals Metabolites with Antibiotic Activity Pharmacology of Benzodiazepines Interferon Gamma Research (2012)
Kynurenine Pathway Metabolites in Humans: Disease and Healthy States
Yiquan Chen
International Journal of Tryptophan Research : IJTR, 2, 1-19 (2009)
The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease
Anna Zinger
Parkinson's Disease (2011)
Linnéa Asp et al.
Journal of inflammation (London, England), 8, 25-25 (2011-10-11)
The kynurenine pathway (KP) is the main route of tryptophan degradation in the human body and generates several neuroactive and immunomodulatory metabolites. Altered levels of KP-metabolites have been observed in neuropsychiatric and neurodegenerative disorders as well as in patients with

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Ist gelöstes Kynurenine bei -20°C haltbar und wenn ja wie lang?

    1 answer
    1. The stability of the solution at -20 °C is not determined. Upon resuspension of L-Kynurenine, it is recommended to store solutions at 15-25 °C. The resuspended product is stable for 6 months when properly stored. It is also recommended to protect this product from light.

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