I5659

Idebenon

≥98% (HPLC), powder

• Synonym(e): 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
• Empirische Formel (Hill-System): C₁₉H₃₀O₅
• CAS-Nummer: 58186-27-9
• Molekulargewicht: 338.44
• MDL-Nummer: MFCD00274552
• UNSPSC-Code: 12352204
• PubChem Substanz-ID: 329815386
• NACRES: NA.25

Eigenschaften

• product name: Idebenon, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• Form: powder
• Löslichkeit: methanol: 50 mg/mL, clear to slightly hazy
• Lagertemp.: room temp
• SMILES String: O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O
• InChI: 1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
• InChIKey: JGPMMRGNQUBGND-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Idebenone is a short-chain benzoquinone drug.

Anwendung

Idebenone has been used:

• to treat mutant myocilin (mMYOC) cells for drug treatment assay
• to validate C2C12 secondary cell screening assay
• to treat obese mice, to test whether idebenone and CoQ10 bind directly to peroxisome proliferator-activated receptor (PPAR)LBDs, His-tagged PPARα, δ and γ LBDs

Biochem./physiol. Wirkung

Idebenone is used in the treatment of visual impairment in adolescents and adults with Leber′s hereditary optic neuropathy (LHON). It serves as an antioxidant. It helps to guard the heart muscle against oxidative stress.

A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable