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Dokumente

I1759

Sigma-Aldrich

Isosorbiddinitrat

powder

Synonym(e):

ISDN

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About This Item

Empirische Formel (Hill-System):
C6H8N2O8
CAS-Nummer:
87-33-2
Molekulargewicht:
236.14
MDL-Nummer:
MFCD00868238
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24895946

Form

powder

Enthält

~60% lactose

Farbe

white

Löslichkeit

organic solvents: soluble (alcohol, acetone and ether)

SMILES String

[H][C@@]1([C@@]([H])(O[N+]([O-])=O)CO2)[C@@]2([H])[C@]([H])(O[N+]([O-])=O)CO1

InChI

1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2

InChIKey

MOYKHGMNXAOIAT-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Nitric oxide (NO) donor and nitrovasodilator. Induces stimulation of corpus mucin biosynthesis in vivo. Used to study the role of nitric oxide in the control of cell growth.

Piktogramme

FlameExclamation mark
GHS02,GHS07

Signalwort

Warning

H-Sätze

H207,H302

Gefahreneinstufungen

Acute Tox. 4 Oral - Desen. Expl. 3

Lagerklassenschlüssel

4.1A - Other explosive hazardous materials

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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C Sciorati et al.
British journal of pharmacology, 122(4), 687-697 (1998-01-10)
1. The role of nitric oxide (NO) in the control of cell growth is controversial since both stimulation and (more often) inhibition have been demonstrated in various cell types. In order to reinvestigate the problem and identify the sites of
S Fujii et al.
The American journal of physiology, 274(5 Pt 1), G857-G862 (1998-06-05)
Recently, in vivo electron paramagnetic resonance (EPR) spectroscopy and imaging have been widely used to investigate free radical distribution and metabolism in tissues, organs, and whole body of small animals. Endogenous nitric oxide (NO) is an attractive target of this
J A Franciosa
American heart journal, 110(1 Pt 2), 245-250 (1985-07-01)
Nitrates are widely used for the management of congestive heart failure (CHF), as well as angina pectoris. In both situations, nitrates significantly increase exercise capacity. The mechanism of this beneficial effect is unclear, especially in CHF. Isosorbide dinitrate reduces pulmonary
Lidong Na et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 301-306 (2012-11-20)
The purpose of this paper is to study the potential of N-succinyl chitosan as a novel permeation enhancer for the intranasal absorption of isosorbide dinitrate (ISDN). A series of N-succinyl chitosan (NSCS) with different degree of succinylation (DS) and molecular
Yongliang Jia et al.
International journal of cardiology, 157(3), 330-340 (2011-01-22)
Danshen dripping pill (DSP) is a popular Chinese medicinal product and often compared with isosorbide dinitrate (ISDN) in treating coronary heart disease angina pectoris. Over 100 randomized controlled trials (RCT) have been published in Chinese language but have not been
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