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G7048

Sigma-Aldrich

Proguanil -hydrochlorid

≥95% (HPLC)

Synonym(e):

Chlorguanid, N1-(4-Chlorphenyl)-N5-isopropylbiguanid

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CHF 95.40
50 MG
CHF 326.00

CHF 95.40

Voraussichtliches Versanddatum29. Mai 2025

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10 MG
CHF 95.40
50 MG
CHF 326.00

About This Item

Empirische Formel (Hill-System):
C11H16ClN5·HCl
CAS-Nummer:
637-32-1
Molekulargewicht:
290.19
EG-Nummer:
211-283-7
MDL-Nummer:
MFCD01732193
UNSPSC-Code:
51101906
PubChem Substanz-ID:
329799959
NACRES:
NA.77

CHF 95.40

Voraussichtliches Versanddatum29. Mai 2025

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Qualitätsniveau

100

Assay

≥95% (HPLC)

Form

solid

Lagerbedingungen

desiccated

Löslichkeit

acetonitrile: water: ~1 mg/mL (60/40)

Ersteller

AstraZeneca

Lagertemp.

2-8°C

SMILES String

Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1

InChI

1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H

InChIKey

SARMGXPVOFNNNG-UHFFFAOYSA-N

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Anwendung

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

Biochem./physiol. Wirkung

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Leistungsmerkmale und Vorteile

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000053138
0000053137
0000186344
0000186343
050M4719V

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Die Dokumentenbibliothek aufrufen

Allan Pamba et al.
Blood, 120(20), 4123-4133 (2012-09-21)
Drug-induced acute hemolytic anemia led to the discovery of G6PD deficiency. However, most clinical data are from isolated case reports. In 2 clinical trials of antimalarial preparations containing dapsone (4,4'-diaminodiphenylsulfone; 2.5 mg/kg once daily for 3 days), 95 G6PD-deficient hemizygous
Miriam K Laufer et al.
PloS one, 7(8), e42284-e42284 (2012-08-23)
The predominance of chloroquine-susceptible falciparum malaria in Malawi more than a decade after chloroquine's withdrawal permits contemplation of re-introducing chloroquine for targeted uses. We aimed to compare the ability of different partner drugs to preserve chloroquine efficacy and prevent the
Carine Van Malderen et al.
Malaria journal, 11, 139-139 (2012-05-02)
Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal disease. Chlorproguanil-dapsone-artesunate (CDA) was a promising artemisinin-based combination therapy
Rachida Tahar et al.
Acta tropica, 125(2), 214-219 (2012-10-23)
Rapid diagnostic tests (RDTs) are affordable, alternative diagnostic tools. The present study aimed to evaluate RDTs available in Cameroon and compare their characteristics to follow the parasitological response of patients for 28 days. Malaria diagnosis was assessed in 179 febrile
Nicholas Fisher et al.
The Journal of biological chemistry, 287(13), 9731-9741 (2012-01-28)
Atovaquone is an anti-malarial drug used in combination with proguanil (e.g. Malarone(TM)) for the curative and prophylactic treatment of malaria. Atovaquone, a 2-hydroxynaphthoquinone, is a competitive inhibitor of the quinol oxidation (Q(o)) site of the mitochondrial cytochrome bc(1) complex. Inhibition
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