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G5918

Sigma-Aldrich

GR 113808

≥98% (HPLC), solid

Synonym(e):

1-[2-[(Methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate

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10 MG
CHF 187.00
50 MG
CHF 658.00

CHF 187.00

Voraussichtliches Versanddatum29. Mai 2025

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10 MG
CHF 187.00
50 MG
CHF 658.00

About This Item

Empirische Formel (Hill-System):
C19H27N3O4S
CAS-Nummer:
144625-51-4
Molekulargewicht:
393.50
MDL-Nummer:
MFCD00912901
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278311
NACRES:
NA.77

CHF 187.00

Voraussichtliches Versanddatum29. Mai 2025

Bulk-Bestellung anfordern

Assay

≥98% (HPLC)

Form

solid

Farbe

white to light pink

Löslichkeit

DMSO: >20 mg/mL

Ersteller

GlaxoSmithKline

Lagertemp.

2-8°C

SMILES String

Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c3ccccc13

InChI

1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3

InChIKey

MOZPSIXKYJUTKI-UHFFFAOYSA-N

Angaben zum Gen

human ... HTR4(3360)
rat ... Htr3a(79246) , Htr4(25324)

Anwendung

GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca2+) transients in rat ventricular cardiomyocytes.[1] It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.[2]

Biochem./physiol. Wirkung

GR 113808 is a 5-HT4 serotonin receptor antagonist.

Leistungsmerkmale und Vorteile

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Sold for research purposes under agreement from Glaxo­Smith­Kline

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000134836
0000099426
0000083061
0000083073
0000066441

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Sigma-Aldrich

Sigma-Aldrich

H6648

Hanks-Salze -Lösung

Polyethylenglykol 400, for synthesis

Sigma-Aldrich

8.07485

Polyethylenglykol

Dispase® II (neutrale Protease, Klasse II) lyophilized, from bacterial, Roche, pkg of 5 × 1 g

Roche

04942078001

Dispase® II (neutrale Protease, Klasse II)

Lucie Rivail et al.
British journal of pharmacology, 143(3), 361-370 (2004-09-08)
A body of evidences suggests that a hydrophobic pocket of the human 5-HT(4) receptor contributes to the high affinity of some bulky 5-HT(4) ligands. A thorough study of this pocket was performed using mutagenesis and molecular modeling. Ligand binding or
Guillaume Lucas et al.
Biological psychiatry, 57(8), 918-925 (2005-04-12)
We recently identified a facilitory control exerted by serotonin4 (5-HT4) receptors on the in vivo firing activity of dorsal raphe nucleus (DRN) serotonergic (5-HT) neurons. However, these findings were based on acute administrations of 5-HT4 receptor agonists and antagonists, which
J Kamei et al.
Neuroscience, 174, 224-233 (2010-11-18)
Respiratory depression is the most well-known and dangerous side-effect of opioid analgesics. Clinical investigations have revealed that this opioid-induced respiratory depression is less severe in patients with chronic pain, but the mechanisms that underlie this phenomenon are unknown. Therefore, the
A N James et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 17(1), 76-82 (2005-01-27)
Selective serotonin reuptake inhibitors (SSRIs) are increasingly used to treat a variety of disorders but have gastrointestinal side-effects. To determine the effects of the SSRI, fluoxetine, on gastric smooth muscle contractility. Fundic, antral, and pyloric circular muscle contractility of guinea
B Godínez-Chaparro et al.
Neuroscience, 222, 379-391 (2012-07-17)
In the present study we determined the role of spinal 5-hydroxytriptamine (5-HT) and 5-HT(4/6/7) receptors in the long-term secondary mechanical allodynia and hyperalgesia induced by formalin in the rat. Formalin produced acute nociceptive behaviors (flinching and licking/lifting) followed by long-term
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