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F5557

Sigma-Aldrich

Fasentin

≥98% (HPLC)

Synonym(e):

N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

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About This Item

Empirische Formel (Hill-System):
C11H9ClF3NO2
CAS-Nummer:
392721-37-8
Molekulargewicht:
279.64
MDL-Nummer:
MFCD01001285
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329799713
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to off-white

Löslichkeit

DMSO: >10 mg/mL

Lagertemp.

room temp

SMILES String

CC(=O)CC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F

InChI

1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)

InChIKey

GNYIJZMBLZXJEJ-UHFFFAOYSA-N

Anwendung

Fasentin has been used as a glucose transporter (GLUT1) inhibitor to assess its effects on the vulnerability of a wide range of triple-negative breast cancer (TNBC) cell lines and to study its effects on cytotoxic drugs induced by hydrocortisone (HC).

Biochem./physiol. Wirkung

Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. Fasentin is a novel inhibitor of glucose uptake that sensitizes cells to FAS-induced cell death. Fasentin selectively sensitized to death ligands, but did not decrease FLIP expression. It alters expression of genes associated with nutrient and glucose deprivation. Fasentin interacted with a unique site in the intracellular channel of the glucose transport protein GLUT1.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sigma-Aldrich

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