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347795

Sigma-Aldrich

Natriumdichloracetat

98%

Synonym(e):

Dichloressigsäure Natriumsalz

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CHF 68.80
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10 G
CHF 68.80
50 G
CHF 296.00

About This Item

Lineare Formel:
Cl2CHCO2Na
CAS-Nummer:
Molekulargewicht:
150.92
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352302
PubChem Substanz-ID:
NACRES:
NA.22

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Qualitätsniveau

Assay

98%

Verunreinigungen

<2% ethyl alcohol

mp (Schmelzpunkt)

198 °C (dec.) (lit.)

Funktionelle Gruppe

chloro

SMILES String

[Na+].[O-]C(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1

InChIKey

LUPNKHXLFSSUGS-UHFFFAOYSA-M

Angaben zum Gen

Verwandte Kategorien

Allgemeine Beschreibung

Natriumdichloracetat ist ein Inhibitor der mitochondrialen Pyruvatdehydrogenase-Kinase (PDK), die eine potente antileukämische Aktivität aufweist.[1][2][3]

Anwendung

Natriumdichloracetat kann als organischer Salzvorläufer für die Synthese von mikroporösem Kohlenstoff verwendet werden, der in der Entwicklung von kohlenstoffhaltigen Adsorbentien zum Einsatz kommt.[4]

Piktogramme

Health hazardExclamation mark

Signalwort

Warning

Gefahreneinstufungen

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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Kunden haben sich ebenfalls angesehen

Yongchong Yang et al.
European journal of medicinal chemistry, 45(9), 4300-4306 (2010-07-29)
A current study shows that sodium dichloroacetate (DCA) can induce cancer cell apoptosis and inhibit tumor growth, but its cytotoxic activity is low (IC(50) > 1000 microM for A549). In this paper, a variety of DCA derivatives were synthesized, and
Frank Comhaire
Medical hypotheses, 120, 65-67 (2018-09-18)
Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic disease the pathogenesis of which remains elusive. Pragmatic proof-of-principle of the hypothetical mechanisms causing the clinical symptoms has been delivered, but it is hard to explain why some patients do respond favourably
Roald A Lambrechts et al.
EMBO molecular medicine, 11(12), e10488-e10488 (2019-11-09)
PKAN, CoPAN, MePAN, and PDH-E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA biosynthesis (PKAN, CoPAN), protein lipoylation
Case report: sodium dichloroacetate (DCA) inhibition of the ?Warburg Effect? in a human cancer patient: complete response in non-Hodgkin?s lymphoma after disease progression with rituximab-CHOP.
Strum SB., et al.
Journal of Bioenergetics and Biomembranes, 45(3), 307-315 (2013)
Han Shen et al.
Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13)
Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to

Artikel

Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.

Questions

1–6 of 6 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Is the product sterile and readily soluble in other solution for intravenous use in medical research?

    1 answer
    1. Unless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption or application to humans or animals. For research purposes, in animal models or in vitro assays, the prepared solution would require filter sterilization.

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  4. How can I make a solution of Product 347795, Sodium dichloroacetate?

    1 answer
    1. Sodium dichloroacetate is soluble in water at 50 mg/ml.

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  5. I have heard that dichloroacetate has been used for cancer treatment.  Is Product 347795, Sodium dichloroacetate, the same chemical?

    1 answer
    1. Some research studies on the use of dichloroacetate as an anti-cancer agent have been performed.  At this time, no dichloroacetate compound or product has been approved for use as an anti-cancer drug.  The common salts of dichloroacetate are sodium and potassium, and these are what have been used in the research studies.  The Sigma-Aldrich products 347795, Sodium Dichloroacetate, and 348082, Potassium Dichloroacetate, are offered for laboratory use only, and are not manufactured or intended for human use.

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  6. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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