E7881

Emodin

from Frangula bark, ≥90% (HPLC), casein Kinase 2 (CK2) inhibitor

• Synonym(e): 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedion, 1,3,8-Trihydroxy-6-methyl-anthrachinon, 6-Methyl-1,3,8-trihydroxy-anthrachinon, Archin, Emodol, Frangula-emodin, Frangulasäure, Rheum-Emodin
• Empirische Formel (Hill-System): C₁₅H₁₀O₅
• CAS-Nummer: 518-82-1
• Molekulargewicht: 270.24
• Beilstein: 1888141
• EG-Nummer: 208-258-8
• MDL-Nummer: MFCD00001207
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278164
• NACRES: NA.77

Eigenschaften

• product name: Emodin, from Frangula bark, ≥90% (HPLC)
• Biologische Quelle: Frangula bark
• Assay: ≥90% (HPLC)
• Löslichkeit: DMSO: soluble; aqueous base: soluble; ethanol: soluble
• Lagertemp.: 2-8°C
• SMILES String: Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
• InChI: 1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
• InChIKey: RHMXXJGYXNZAPX-UHFFFAOYSA-N
• Angaben zum Gen: human ... CSNK2A1(1457) , CSNK2B(1460) , ELA2(1991) , NFKB1(4790) , NKAP(79576) , NKRF(55922)

Beschreibung

Allgemeine Beschreibung

Emodin is an anthraquinone derivative, extracted from rhubarb (Rheum palmatum). It has antibacterial, anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. Emodin exhibits cytotoxic effects, apoptosis and stimulates the expression of hypoxia-inducible factor 1α, glutathione S-transferase P and N-acetyltransferase. It prevents the growth of prostate cancer cells. Emodin is used to treat constipation and hemorrhoid. It displays immunosuppressive and anti-diabetic effects.

Anwendung

Emodin has been used:

• to investigate its regulatory mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury in myocarditis
• as a reference standard for the development and validation of high performance liquid chromatography (HPLC)-photodiode array (PDA) assay method
• to inhibit Tau aggregation
• for direct binding assay

Biochem./physiol. Wirkung

Inhibitor of NF-κB activation and adhesion molecule expression. Casein Kinase 2 (CK2) inhibitor.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves