E101

S-(−)-Eticlopride hydrochloride

≥98% (HPLC), D2 dopamine receptor antagonist, powder

• Synonym(e): FLB 131, S-(−)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride
• Empirische Formel (Hill-System): C₁₇H₂₅ClN₂O₃ · HCl
• CAS-Nummer: 97612-24-3
• Molekulargewicht: 377.31
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278428
• NACRES: NA.77
• MDL number: MFCD00055132
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: S-(−)-Eticlopride hydrochloride, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]27/D −7.2°, c = 0.3 in methanol(lit.)
• storage condition: desiccated
• color: off-white
• solubility: H₂O: soluble >10 mg/mL, ethanol: soluble 2.6 mg/mL, 0.1 M HCl: soluble 7 mg/mL
• SMILES string: Cl.CCN1CCC[C@H]1CNC(=O)c2c(O)c(CC)cc(Cl)c2OC
• InChI: 1S/C17H25ClN2O3.ClH/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2;/h9,12,21H,4-8,10H2,1-3H3,(H,19,22);1H/t12-;/m0./s1
• InChI key: HFJFXXDHVWLIKX-YDALLXLXSA-N
• Gene Information: human ... DRD2(1813)

Beschreibung

Application

S-(−)-Eticlopride hydrochloride has been used in astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments.

Biochem/physiol Actions

Potent and selective D2 dopamine receptor antagonist. Eticlopride is highly specific for DAD2 receptors than pimozide or haloperidol. The gene encoding the D2 dopamine receptor (DRD2) is linked with a several disorders including Parkinson′s disease, schizophrenia, and susceptibility to alcoholism.

Preparation Note

Solutions may be stored at 4° C for several days

Legal Information

Manufactured and sold with the permission of Astra AB.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)