83580

Reserpin

crystallized, ≥99.0% (HPLC)

• Synonym(e): (3β, 16β, 17α, 18β, 20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carbonsäure-methylester
• Empirische Formel (Hill-System): C₃₃H₄₀N₂O₉
• CAS-Nummer: 50-55-5
• Molekulargewicht: 608.68
• Beilstein: 102014
• EG-Nummer: 200-047-9
• MDL-Nummer: MFCD00005091
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329769078
• NACRES: NA.77

Eigenschaften

• Assay: ≥99.0% (HPLC)
• Form: solid
• Optische Aktivität: [α]20/D −123±3°, c = 1% in chloroform
• Qualität: crystallized
• mp (Schmelzpunkt): ~265 °C (dec.)
• SMILES String: CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6
• InChI: 1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
• InChIKey: QEVHRUUCFGRFIF-MDEJGZGSSA-N
• Angaben zum Gen: human ... SLC18A2(6571)

Beschreibung

Allgemeine Beschreibung

Reserpine is an indole alkaloid that irreversibly binds vesicular monoamine transporters VMAT1 and VMAT2. It is a sympatholytic drug useful in treating systemic hypertension.[1]

Anwendung

Reserpine has been used as a test chemical in performance studies.[2]

Biochem./physiol. Wirkung

Hemmt die vesikuläre Aufnahme von Catecholaminen und Serotonin.

Reserpine is used to treat hypertensive pregnancy difficulties.[1] This drug is also considered as antipsychotic and antihypertensive, to regulate high blood pressure.[3]

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H336,H351,H360D
• P-Sätze: P201 - P301 + P312 + P330 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3
• Zielorgane: Central nervous system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves