D4321

Dihydroeponemycin

≥98% (HPLC)

• Empirische Formel (Hill-System): C₂₀H₃₆N₂O₆
• CAS-Nummer: 126463-64-7
• Molekulargewicht: 400.51
• MDL-Nummer: MFCD17215971
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329798798
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D ±35.7°
• Farbe: off-white to light tan
• Löslichkeit: DMSO: ≥1 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CC(C)CCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(CO)CO1
• InChI: 1S/C20H36N2O6/c1-13(2)7-5-6-8-17(25)21-16(10-23)19(27)22-15(9-14(3)4)18(26)20(11-24)12-28-20/h13-16,23-24H,5-12H2,1-4H3,(H,21,25)(H,22,27)/t15-,16-,20+/m0/s1
• InChIKey: IUDBVFIQSSOIDB-TWOQFEAHSA-N

Beschreibung

Biochem./physiol. Wirkung

Dihydroeponemycin is an active derivative of eponemycin an antitumor antibiotic isolated from Streptomyces hygroscopicus. Dihydroeponemycin labels the catalytic threonine residues of the immunoproteasome subunits LMP2 and LMP7 and the constitutive proteasome subunit X, while epoxomicin covalently modifies the N-terminal catalytic threonine residues of the constitutive proteasome (X and Z) and immunoproteasome (LMP7 and MECL1) subunits.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable