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Merck

C1159

Sigma-Aldrich

L-Cycloserin

Synonym(e):

(S)-4-Amino-3-isoxazolidon

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10 MG
CHF 63.30
25 MG
CHF 74.10
100 MG
CHF 187.00
250 MG
CHF 392.00

CHF 63.30


Voraussichtliches Versanddatum29. Mai 2025


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10 MG
CHF 63.30
25 MG
CHF 74.10
100 MG
CHF 187.00
250 MG
CHF 392.00

About This Item

Empirische Formel (Hill-System):
C3H6N2O2
CAS-Nummer:
Molekulargewicht:
102.09
Beilstein:
80799
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352202
eCl@ss:
32160406
PubChem Substanz-ID:
NACRES:
NA.77

CHF 63.30


Voraussichtliches Versanddatum29. Mai 2025


Bulk-Bestellung anfordern

Assay

≥95% (TLC)

Form

powder

mp (Schmelzpunkt)

146 °C

Löslichkeit

H2O: 50 mg/mg protein

Lagertemp.

−20°C

SMILES String

N[C@H]1CONC1=O

InChI

1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m0/s1

InChIKey

DYDCUQKUCUHJBH-REOHCLBHSA-N

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Biochem./physiol. Wirkung

Blocks sphingosine biosynthesis by inhibition of ketosphinganine synthetase. Cytotoxicity toward neuroblastoma and medulloblastoma cells mediated by suppression of ganglioside synthesis.[1]
L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis.
Blocks sphingosine biosynthesis by inhibition of ketosphinganine synthetase. Cytotoxicity toward neuroblastoma and medulloblastoma cells mediated by suppression of ganglioside synthesis.[1]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Elisa Caiola et al.
Cells, 9(8) (2020-07-29)
Non-small-cell lung cancer (NSCLC) cell lines vary in their sensitivity to glutaminase inhibitors, so it is important to identify the metabolic assets underling their efficacy in cancer cells. Even though specific genetic lesions such as in KRAS and LKB1 have
Peirong Hu et al.
Journal of neuroscience research, 94(11), 1152-1168 (2016-09-18)
Currently, presymtomatic hematopoietic stem and progenitor cell transplantation (HSPCT) is the only therapeutic modality that alleviates Krabbe's disease (KD)-induced central nervous system damage. However, all HSPCT-treated patients exhibit severe deterioration in peripheral nervous system function characterized by major motor and
J Cinatl et al.
Anticancer research, 19(6B), 5349-5354 (2000-03-04)
Human neuroblastoma and medulloblastoma express abnormal ganglioside patterns especially GD2 and GM2 which are important for tumour growth. We tested the effects of L-cycloserine (L-CS), a potent inhibitor of synthesis of glycosphingolipids, on the growth, viability and expression of GD2
David M Pereira et al.
Marine drugs, 12(1), 54-68 (2013-12-26)
We describe the effect of a chemically characterized lipophilic extract obtained from Marthasterias glacialis L. against human breast cancer (MCF-7) and human neuroblastoma (SH-SY5Y) cell lines. Evaluation of DNA synthesis revealed that both cell lines were markedly affected in a
Sara Ghezzal et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(2), 158530-158530 (2019-10-28)
The mechanisms leading to the low-grade inflammation observed during obesity are not fully understood. Seeking the initiating events, we tested the hypothesis that the intestine could be damaged by repeated lipid supply and therefore participate in inflammation. In mice, 1-5

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