B3063

BI-78D3

≥98% (HPLC)

• Synonym(e): 4-(2,3-Dihydrobenzol[b][1,4]dioxin-6-yl)-5-(5-nitrothiazol-2-ylthio)-4H-1,2,4-triazol-3-ol
• Empirische Formel (Hill-System): C₁₃H₉N₅O₅S₂
• CAS-Nummer: 883065-90-5
• Molekulargewicht: 379.37
• MDL-Nummer: MFCD12912396
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329773213

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: tan
• Löslichkeit: DMSO: >10 mg/mL
• Lagertemp.: −20°C
• SMILES String: Oc1nnc(Sc2ncc(s2)[N+]([O-])=O)n1-c3ccc4OCCOc4c3
• InChI: 1S/C13H9N5O5S2/c19-11-15-16-12(25-13-14-6-10(24-13)18(20)21)17(11)7-1-2-8-9(5-7)23-4-3-22-8/h1-2,5-6H,3-4H2,(H,15,19)
• InChIKey: QFRLDZGQEZCCJZ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

BI-78D3 is a substrate competitive inhibitor of JNK. JNK′s binds to JNK-interacting protein-1 (JIP1) (scaffolding protein) through high affinity D-domain on JIP1. This interaction is needed to place JNK next to target protein. BI-78D3 is a mimetic of a critical peptide structure of JIP1 which binds to JNK away from ATP binding domain preventing JIP1 JNK interaction thus acting as a substrate competitive inhibitor both in vitro and in vivo. The compound represents a growing number of modern kinase inhibitors acting at protein protein interacting areas (scaffolding) rather than ATP binding pockets.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable