Pentagastrin is subject to oxidation in solution. A pentagastrin solution in DMF can be stored frozen to protect the TRP and MET from oxidation. Further protection from oxidation can be insured if the solution is prepared with degassed solvent and the solution is stored under an inert gas such as argon or dry nitrogen gas.
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B1636
Pentagastrin
≥95% (HPLC), powder, CCK2 receptor agonist
Synonym(e):
Peptavlon, Petogasrin, N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide
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25 MG
CHF 239.00
100 MG
CHF 777.00
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25 MG
CHF 239.00
100 MG
CHF 777.00
About This Item
Empirische Formel (Hill-System):
C37H49N7O9S
CAS-Nummer:
Molekulargewicht:
767.89
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
Empfohlene Produkte
Produktbezeichnung
Pentagastrin, ≥95% (HPLC), powder
Assay
≥95% (HPLC)
Form
powder
Lagerbedingungen
(Keep container tightly closed in a dry and well-ventilated place.)
Farbe
white to off-white
Löslichkeit
DMF: 20 mg/mL, clear, colorless to faint yellow or tan
Lagertemp.
−20°C
SMILES String
CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O
InChI
1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)
InChIKey
NEYNJQRKHLUJRU-UHFFFAOYSA-N
Angaben zum Gen
mouse ... Cckbr(12426)
rat ... Cckar(24889) , Cckbr(25706)
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Amino Acid Sequence
Boc-Bal-Trp-Met-Asp-Phe-NH2
Allgemeine Beschreibung
Research area: Immunology & cytokines
Anwendung
Pentagastrin has been used to bidirectionally modulate lateral nucleus of the amygdala (LA) activity.[1] It has also been used as a cholecystokinin-2 receptor (CCK2R) agonist to block the receptor binding for Ga-DOTA-MGS5 in AR42J rat pancreatic cell lines during cell uptake and receptor binding studies.[2]
Biochem./physiol. Wirkung
Pentagastrin, a synthetic polypeptide is a gastrin analog. It contains the five C-terminal amino acids of gastrin.[3] It acts as a cholecystokinin-2 (CCK2) receptor/ cholecystokinin-B (CCKB) receptor agonist.[4] Pentagastrin stimulates the secretion of pepsin and gastric acid.[3] It also aids in the evaluation of gastric acid secretory function.[5] Pentagastrin exhibits panicogenic/ anxiogenic effects and thereby induces panic attacks in panic disorder (PD) patients.[4]
Antikörper
Inhibitor
Produkt-Nr.
Beschreibung
Preisangaben
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
T D Barrett et al.
British journal of pharmacology, 166(5), 1684-1693 (2012-02-04)
JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide] is a novel antagonist at cholecystokinin CCK(2) receptors with good pharmacokinetic properties and represents a novel mechanism for the treatment of gastro-oesophageal reflux disease (GORD). The purpose of the present study was to determine whether chronic treatment with
Katsunori Iijima et al.
Journal of gastroenterology, 47(12), 1290-1297 (2012-05-03)
The association of Helicobacter pylori infection with aspirin-induced gastropathy is controversial. H. pylori infection exerts diverse effects on gastric acid secretion. In this study, the interaction between H. pylori infection and aspirin was investigated with reference to the individual gastric
L Singh et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(4), 1130-1133 (1991-02-15)
The effect of neuropeptide cholecystokinin (CCK) receptor agonists and antagonists was examined in the rat elevated X-maze model of anxiety. The selective CCK-B receptor antagonists CI-988 (PD 134308) and L-365,260 produced anxiolytic-like effects, whereas MK-329, a CCK-A receptor antagonist, was
Y Keto et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(2), 147-153 (2011-11-10)
Gastroduodenal acidification has been reported to aggravate upper abdominal discomfort and pain that are symptoms suffered by functional dyspepsia (FD) patients. Delayed gastric emptying and hypersensitivity to gastric distension (GD) contribute importantly to the pathophysiology of FD. In the present
Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus
Lee Y, et al.
Testing, 8(1), 203-203 (2017)
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How can Pentagastrin, Product B1636, solutions be stored?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the shelf-life of Pentagastrin, Product B1636?
1 answer-
This product does not have any official shelf-life or expiration dating associated with it. The only date shown on the certificate of analysis will be the QC Release date. For customers whose systems require formal date management, use of a date one year from shipment is supported by our terms and conditions of supply.
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What is Pentagastrin, Product B1636, soluble in?
1 answer-
Pentagastrin is soluble in either dimethylformamide (DMF) or DMSO at a concentration of 20 mg/mL.
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