A9861

Aurapten

≥98% (HPLC)

• Synonym(e): 7-Geranyloxy-cumarin, 7-{[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-oxy}-2H-1-benzopyran-2-on
• Empirische Formel (Hill-System): C₁₉H₂₂O₃
• CAS-Nummer: 495-02-3
• Molekulargewicht: 298.38
• MDL-Nummer: MFCD00075948
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329771062
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: >20 mg/mL
• Lagertemp.: −20°C
• SMILES String: C\C(C)=C\CC\C(C)=C\COc1ccc2C=CC(=O)Oc2c1
• InChI: 1S/C19H22O3/c1-14(2)5-4-6-15(3)11-12-21-17-9-7-16-8-10-19(20)22-18(16)13-17/h5,7-11,13H,4,6,12H2,1-3H3/b15-11+
• InChIKey: RSDDHGSKLOSQFK-RVDMUPIBSA-N

Beschreibung

Allgemeine Beschreibung

Auraptene (7-geranyloxycoumarin) is a prenyloxycoumarin, that is abundantly present in nature. It is produced by several plant species, such as Rutaceae and Umbeliferae (Apiaceae) families.[1]

Biochem./physiol. Wirkung

Auraptene is an ACAT inhibitor and estrogen receptor modulator.

Auraptene is an estrogen receptor modulator that also acts as an ACAT inhibitor. It displays anti-tumor effects in several xenograft and chemically-induced murine tumor models. Auraptene induces apoptosis and is anti-proliferative in cancer cell lines. It has agonistic properties against PPARs, and interferes with lipid and cholesterol production by inhibiting ACAT (IC50 = 4 uM).

Auraptene (7-geranyloxycoumarin) possesses anti-oxidant, anti-bacterial, anti-inflammatory and anti-tumor activities.[2]

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable