74155

Nonactin

from Streptomyces sp., ≥97.0% (TLC)

• Synonym(e): Ammonium-Ionophor
• Empirische Formel (Hill-System): C₄₀H₆₄O₁₂
• CAS-Nummer: 6833-84-7
• Molekulargewicht: 736.93
• Beilstein: 76434
• EG-Nummer: 229-911-3
• UNSPSC-Code: 51101500
• PubChem Substanz-ID: 24886652
• NACRES: NA.85

Eigenschaften

• Biologische Quelle: Streptomyces sp.
• Qualitätsniveau: 200
• Assay: ≥97.0% (TLC)
• Form: powder
• Farbe: white to faint yellow
• Wirkungsspektrum von Antibiotika: Gram-positive bacteria
• Wirkungsweise: DNA synthesis | interferes; cell membrane | interferes; enzyme | inhibits
• Lagertemp.: 2-8°C
• SMILES String: C[C@H]1C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O[C@H](C)C[C@H]3CC[C@H](O3)[C@H](C)C(=O)O[C@@H](C)C[C@@H]4CC[C@@H](O4)[C@@H](C)C(=O)O[C@H](C)C[C@H]5CC[C@H](O5)[C@H](C)C(=O)O1
• InChI: 1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
• InChIKey: RMIXHJPMNBXMBU-QIIXEHPYSA-N

Beschreibung

Allgemeine Beschreibung

kann die Homologen Monactin und Dinactin enthalten

Chemical structure: macrolide

Anwendung

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, as an uncoupler of oxidative phosphorylation, and to inhibit surface expression of certain heat shock proteins (HSP60) .

Biochem./physiol. Wirkung

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is a uncoupler of oxidative phosphorylation .

Verpackung

5 mg

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.Moisturesensitive. Keep in a dry place.

Natürliches Macrotetrolid

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)