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486R-1

Sigma-Aldrich

Somatostatin Receptor 2A (EP149) Rabbit Monoclonal Primary Antibody

Synonym(e):

SSTR2A

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About This Item

UNSPSC-Code:
41116161
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Biologische Quelle

rabbit

Qualitätsniveau

500

Konjugat

unconjugated

Antikörperform

IgG fraction of antiserum

Antikörper-Produkttyp

primary antibodies

Klon

EP149

Beschreibung

For In Vitro Diagnostic Use in Select Regions

Form

buffered aqueous solution

Speziesreaktivität

human

Verpackung

vial of 0.1 mL (concentrate (486R-14))
vial of 0.1 mL (concentrate (486R-14-RUO) Research Use Only)
vial of 0.5 mL (concentrate (486R-15))
vial of 1.0 mL (concentrate (486R-16))
vial of 1.0 mL (concentrate (486R-16-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute (486R-17-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute ready-to-use (486R-17))
vial of 7.0 mL (pre-dilute ready-to-use (486R-18))
vial of 7.0 mL (pre-dilute ready-to-use (486R-18-RUO) Research Use Only)

Hersteller/Markenname

Cell Marque®

Methode(n)

immunohistochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:25-1:100 (concentrated))

Isotyp

IgG

Kontrolle

lymph node, pancreas, (meningioma)

Versandbedingung

wet ice

Lagertemp.

2-8°C

Visualisierung

cytoplasmic (
), membranous

Allgemeine Beschreibung

Somatostatin Receptor 2A (SSTR2A) is a protein highly expressed in pancreas binding somatostatin and inhibiting pancreatic enzyme secretion. SSTR2A is used as a marker for identifying meningioma from other spindle-cell tumors such as solitary fibrous tumor. SSTR2A is more frequently expressed in higher grade meningiomas and associated to its microvessel proliferation. SSTR2A has demonstrated utility as a diagnostic marker for follicular dendritic cell sarcomas and some other related tumors.

Qualität

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Angaben zur Herstellung

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Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: [email protected]

Rechtliche Hinweise

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000399562
0000399574
0000386911
0000377572
0000369985

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Die Dokumentenbibliothek aufrufen

Li-Li Tao et al.
The American journal of surgical pathology, 43(3), 374-381 (2018-12-27)
SSTR2a, a member of the somatostatin receptor family, has been used as a diagnostic marker of meningioma. However, the expression of SSTR2a in follicular dendritic cells (FDCs) and their related tumors has been poorly characterized. This study aimed to assess
Camille Boulagnon-Rombi et al.
Journal of neuropathology and experimental neurology, 76(4), 289-298 (2017-03-25)
The differential diagnosis between meningioma and others tumors can be challenging. This study aimed to evaluate different immunohistochemical markers for the differential diagnosis between meningioma and their morphological mimics. Immunohistochemistry was performed on tissue microarray with antiepithelial membrane antigen (EMA)
V Barresi et al.
Oncology reports, 20(3), 485-492 (2008-08-13)
Somatostatin anti-proliferative and anti-angiogenic activities, together with the expression of somatostatin receptors (sstrs), account for the use of somatostatin analogues in the treatment of human tumours. In the present study, sstr2A immunohistochemical expression was analyzed in grade II and III
Somatostatin receptor 2a is a more sensitive diagnostic marker of meningioma than epithelial membrane antigen.
Joshua R Menke et al.
Acta neuropathologica, 130(3), 441-443 (2015-07-22)
Balrik Kailey et al.
American journal of physiology. Endocrinology and metabolism, 303(9), E1107-E1116 (2012-08-31)
Somatostatin-14 (SST) inhibits insulin and glucagon secretion by activating G protein-coupled somatostatin receptors (SSTRs), of which five isoforms exist (SSTR1-5). In mice, the effects on pancreatic β-cells are mediated by SSTR5, whereas α-cells express SSTR2. In both cell types, SSTR

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