11702

Bacitracin

from Bacillus licheniformis, ≥65 IU/mg

• Synonym(e): Altracin, Bacitracin A
• Empirische Formel (Hill-System): C₆₆H₁₀₃N₁₇O₁₆S
• CAS-Nummer: 1405-87-4
• Molekulargewicht: 1422.69
• EG-Nummer: 215-786-2
• MDL-Nummer: MFCD00062640
• UNSPSC-Code: 51282002
• PubChem Substanz-ID: 57646949
• NACRES: NA.85

Eigenschaften

• Biologische Quelle: Bacillus licheniformis
• Qualitätsniveau: 200
• Form: powder
• Spezifische Aktivität: ≥65 IU/mg
• Farbe: white to pale buff
• Wirkungsspektrum von Antibiotika: Gram-positive bacteria
• Wirkungsweise: cell wall synthesis | interferes
• Lagertemp.: 2-8°C
• SMILES String: [H]N1[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)C3CSC(=N3)C(N)C(C)CC)[C@@H](C)CC)C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](Cc4ccccc4)C1=O
• InChI: 1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-/m0/s1
• InChIKey: CLKOFPXJLQSYAH-RNHDWVCBSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: peptide

Anwendung

Bacitracin is used to study disruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. It is also used to study the biosynthesis of sterols and squalene.
Bacitracin has been used:

• as a protease inhibitor[1]
• as a control antibiotic[2]
• for the calibration in size exclusion chromatography[3]

Biochem./physiol. Wirkung

Bacitracin has been shown to decrease vancomycin-resistant Enterococcus faecium population in intestine.[4]

Bacitracin is a peptide antibiotic.
Antimicrobial spectrum: Gram-positive bacteria.
Mode of Action: Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate.

Verpackung

5G, 25 G

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)