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G2417

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Gabexat-Mesylat

analytical standard, for drug analysis

Synonym(e):

4-[[6-[(Aminoiminomethyl)-amino]-1-oxohexyl]-oxyl]-benzoesäure-ethylester -mesylat (Salz), FOY, Megacart

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About This Item

Empirische Formel (Hill-System):
C16H23N3O4 · CH4O3S
CAS-Nummer:
56974-61-9
Molekulargewicht:
417.48
MDL-Nummer:
MFCD00210299
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329799903
NACRES:
NA.24

Qualität

analytical standard, for drug analysis

Qualitätsniveau

200

Form

solid

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Format

neat

SMILES String

CS(O)(=O)=O.CCOC(=O)c1ccc(OC(=O)CCCCCNC(N)=N)cc1

InChI

1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)

InChIKey

DNTNDFLIKUKKOC-UHFFFAOYSA-N

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Allgemeine Beschreibung

Gabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases, which finds therapeutic applications in the treatment of disseminated intravascular coagulation and pancreatitis. It also plays the role of an anticoagulant in hemodialysis therapy.

Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Analysenzertifikate (COA)

Lot/Batch Number
081K1764

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Tomoki Nishiyama et al.
The American journal of emergency medicine, 30(7), 1219-1223 (2011-12-30)
We hypothesized that antithrombin is more effective for disseminated intravascular coagulation (DIC) than is gabexate mesilate, which is a protease inhibitor, suggested from the previous studies. Initially, we compared the effects of antithrombin and gabexate mesilate for treating infection-related DIC.
S Aosasa et al.
Shock (Augusta, Ga.), 15(2), 101-105 (2001-02-28)
If the inflammatory response becomes excessive or uncontrolled by some stimuli, inappropriate inflammatory responses occur. Monocytes are extremely important cells for regulating the cytokine network and tumor necrosis factor alpha (TNFalpha) and interleukin- (IL) 10, which are mainly synthesized by
Hirofumi Noguchi et al.
Cell transplantation, 21(2-3), 509-516 (2012-07-17)
For islet transplantation, maintaining organ viability after pancreas procurement is critically important for optimal graft function and survival. We recently reported that islet yield was significantly higher in the modified ET-Kyoto (MK) solution, which includes a trypsin inhibitor (ulinastatin), compared
Kohei Uchimura et al.
American journal of physiology. Renal physiology, 303(7), F939-F943 (2012-07-27)
Aldosterone plays an important role in the regulation of blood pressure by modulating the activity of the epithelial sodium channel (ENaC) that consists of α-, β-, and γ-subunits. Aldosterone induces a molecular weight shift of γENaC from 85 to 70
James A Reihill et al.
Biomolecules, 10(4) (2020-04-02)
Epithelial barrier dysfunction, characteristic of allergic airway disease may be, at least in part, due to the action of allergen-associated protease activities. Cockroach allergy is a major global health issue, with cockroaches containing considerable serine trypsin-like protease (TLP) activity. The
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Artikel

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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