90221

Retigabin

analytical standard

• Synonym(e): N-(2-Amino-4-(4-fluorbenzylamino)-phenyl)-carbaminsäure-ethylester, D-23129, Ezogabin
• Empirische Formel (Hill-System): C₁₆H₁₈FN₃O₂
• CAS-Nummer: 150812-12-7
• Molekulargewicht: 303.33
• Beilstein: 8072099
• MDL-Nummer: MFCD04307735
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329769861
• NACRES: NA.24

Eigenschaften

• Qualität: analytical standard
• Qualitätsniveau: 100
• Assay: ≥98.0% (HPLC)
• Haltbarkeit: limited shelf life, expiry date on the label
• Arzneimittelkontrolle: USDEA Schedule IV
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• Verunreinigungen: ≤1.0% water (calc. from elemental analysis)
• Anwendung(en): forensics and toxicology; veterinary
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: FC1=CC=C(CNC2=CC(N)=C(NC(OCC)=O)C=C2)C=C1
• InChI: 1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
• InChIKey: PCOBBVZJEWWZFR-UHFFFAOYSA-N
• Angaben zum Gen: human ... KCNQ1(3784) , KCNQ2(3785) , KCNQ3(3786) , KCNQ4(9132) , KCNQ5(56479)

Beschreibung

Allgemeine Beschreibung

Retigabine is an antiepileptic drug, which activates neuronal KCNQ-type K+ channels by inducing a large hyperpolarizing shift of steady-state activation.

Anwendung

Retigabine may be used as a reference standard in the determination of retigabine in biological matrices using high-performance liquid chromatography coupled with tandem mass spectrometry with positive ion atmospheric pressure chemical ionization (HPLC-APCI-MS/MS).

Biochem./physiol. Wirkung

Retigabine (Ezogabine) is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity.

Sicherheitshinweise

• Piktogramme: GHS06,GHS09
• Signalwort: Danger
• H-Sätze: H301 + H331,H410
• P-Sätze: P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable