574776

Swinholide A, Theonella swinhoei

A dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro.

• Synonym(e): Swinholide A, Theonella swinhoei
• Empirische Formel (Hill-System): C₇₈H₁₃₂O₂₀
• CAS-Nummer: 95927-67-6
• Molekulargewicht: 1389.87
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: oil
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: colorless
• Löslichkeit: acetone: soluble; ethanol: soluble
• Versandbedingung: ambient
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A dimeric dilactone macrolide isolated from the marine sponge Theonella swinhoei. Cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal activity.

A dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal properties.

Biochem./physiol. Wirkung

Cell permeable: no

Primary Target
Disrupts the actin cytoskeleton

Product does not compete with ATP.

Reversible: no

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Saito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
Doi, M., et al. 1991. J. Org. Chem. 56, 3629.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• H-Sätze: H413
• P-Sätze: P273 - P501
• Gefahreneinstufungen: Aquatic Chronic 4
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable