208922-M

CaMKII Inhibitor, CK59

The CaMKII Inhibitor, CK59, also referenced under CAS 140651-18-9, controls the biological activity of CaMKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(e): CaMKII Inhibitor, CK59, 2-(2-Hydroxyethylamino)-6-aminohexylcarbamic acid tert-butyl ester-9-isopropylpurine, CK59
• Empirische Formel (Hill-System): C₂₁H₃₇N₇O₃
• CAS-Nummer: 140651-18-9
• Molekulargewicht: 435.56
• MDL-Nummer: MFCD09262258
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: semisolid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: yellow
• Löslichkeit: DMSO: 10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: [nH]1nc(c(c1N)N=Nc2ccc(cc2)O)N
• InChI: 1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)
• InChIKey: AYZRKFOEZQBUEA-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable Olomoucine (Cat. Nos. 495620 & 495624) analog that acts as a CaMKII inhibitor (IC₅₀<10 µM) and inhibits insulin-stimulated glucose uptake (IC₅₀ ≤5 µM) and GLUT4 membrane translocation (IC₅₀ = 100 µM) in 3T3-L1 adipocytes.

A cell-permeable Olomoucine analog that acts as a CaMKII inhibitor (IC₅₀<10 M) and inhibits insulin-stimulated glucose uptake (IC₅₀ ≤5 M) and GLUT4 membrane translocation (IC₅₀ = 100 M) in 3T3-L1 adipocytes.

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution aliquot, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Konstantopoulos, N., et al. 2007. Endocrinology, 148, 374.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable