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700070P

Avanti

trihydroxycholestanoic acid

Avanti Research™ - A Croda Brand

Synonym(e):

3α,7α,12α-trihydroxycholestanoic acid

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About This Item

Empirische Formel (Hill-System):
C27H46O5
CAS-Nummer:
547-98-8
Molekulargewicht:
450.65
UNSPSC-Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

Form

powder

Verpackung

pkg of 1 × 1 mg (700070P-1mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand

Lipid-Typ

bile acids

Versandbedingung

dry ice

Lagertemp.

−20°C

InChI

1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1

InChIKey

CNWPIIOQKZNXBB-VCVMUKOKSA-N

Verwandte Kategorien

Allgemeine Beschreibung

Trihydroxycholestanoic acid (THCA) is an oxidative metabolite of cholesterol and a precursor to bile acids. Very long-chain acyl-CoA synthetase (VLCS) associated with endoplasmic reticulum and peroxisomes activates THCA, the C27 bile acid intermediate.

Anwendung

Trihydroxycholestanoic acid has been used as a sterol to test its reactivity with human mincle protein.

Biochem./physiol. Wirkung

Trihydroxycholestanoic acid (THCA) and dihydroxycholestanoic (DHCA) accumulation is observed in Zellweger syndrome and cholestatic liver disease. The synthesis of (25R)-isomer of DHCA and THCA is favored by mitochondrial 27-hydroxylase.

Verpackung

5 mL Amber Glass Screw Cap Vial (700070P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

No data available

Flammpunkt (°C)

No data available

Analysenzertifikate (COA)

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S Ferdinandusse et al.
Journal of lipid research, 42(1), 137-141 (2001-02-13)
We identified a new peroxisomal disorder caused by a deficiency of the enzyme alpha-methylacyl-coenzyme A (CoA) racemase. Patients with this disorder show elevated plasma levels of pristanic acid and the bile acid intermediates di- and trihydroxycholestanoic acid (DHCA and THCA)
James O'Byrne et al.
The Journal of biological chemistry, 278(36), 34237-34244 (2003-06-18)
Bile acid-CoA:amino acid N-acyltransferase (BACAT) catalyzes the conjugation of bile acids to glycine and taurine for excretion into bile. By use of site-directed mutagenesis and sequence comparisons, we have identified Cys-235, Asp-328, and His-362 as constituting a catalytic triad in
Ryoko Kiyotake et al.
The Journal of biological chemistry, 290(42), 25322-25332 (2015-08-25)
C-type lectin receptors (CLRs) are an emerging family of pattern recognition receptors that recognizes pathogens or damaged tissue to trigger innate immune responses. However, endogenous ligands for CLRs are not fully understood. In this study, we sought to identify an

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