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141101P

Avanti

Brain Extract Polar

Avanti Research™ - A Croda Brand

Synonym(e):

Brain Polar Lipid Extract (Porcine)

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100 MG
CHF 253.00
500 MG
CHF 784.00

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100 MG
CHF 253.00
500 MG
CHF 784.00

About This Item

CAS-Nummer:
86088-88-2
MDL-Nummer:
MFCD00066101
UNSPSC-Code:
12352211
NACRES:
NA.25

CHF 253.00

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Form

powder

Verpackung

pkg of 1 × 100 mg (141101P-100mg)
pkg of 5 × 100 mg (141101P-500mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand

Lipid-Typ

lipid extracts

Versandbedingung

dry ice

Lagertemp.

−20°C

Allgemeine Beschreibung

Brain Extract Polar comprises phosphatidylethanolamine as a major lipid component. It also contains phosphatidylserine and phosphatidylcholine. The minor components include the phosphatidic acid and phosphatidylinositol.
Brain Polar Lipid Extract is derived from the total lipid extract by precipitation with acetone followed by extraction of the acetone insoluble material with diethyl ether.

Anwendung

Brain Extract Polar has been used in parallel artificial membrane permeability assay (PAMPA) for coating membrane to evaluate blood brain-barrier permeability,[1][2] and for drug permeability studies.[3]

Biochem./physiol. Wirkung

Lipid extracts from the mammalian tissues like brain, kidney and liver are used in generating model membranes for mimicking real membranes.[4] Brain lipid, especially the polar fraction play a key role in the inhibition of prion seeded amyloid formation.[5]

Verpackung

5 mL Clear Glass Sealed Ampule (141101P-100mg)
5 mL Clear Glass Sealed Ampule (141101P-500mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

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Analysenzertifikate (COA)

Lot/Batch Number

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Die Dokumentenbibliothek aufrufen

Rapid screening of brain-penetrable antioxidants from natural products by blood-brain barrier specific permeability assay combined with DPPH recognition
Zhu J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 151, 42-48 (2018)
Irene Paterniti et al.
PloS one, 6(1), e15937-e15937 (2011-02-08)
Primary traumatic mechanical injury to the spinal cord (SCI) causes the death of a number of neurons that to date can neither be recovered nor regenerated. During the last years our group has been involved in the design, synthesis and
Laura Campello et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(1), 142-159 (2020-02-07)
It is well established that oxidative stress and inflammation are common pathogenic features of retinal degenerative diseases. ITH12674 is a novel compound that induces the transcription factor Nrf2; in so doing, the molecule exhibits anti-inflammatory, and antioxidant properties, and affords
David S Wexler et al.
Journal of biomolecular screening, 10(4), 383-390 (2005-06-21)
Solubility and permeability are intimately linked in drug absorption processes. They have, however, been traditionally assayed separately. To support this linkage, a combined solubility/permeability assay was developed for determining absorption properties of chemical entities. First, solubility is determined at 4
Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs
Hallifax D, et al.
European Journal of Pharmaceutical Sciences, 45(5), 570-574 (2012)
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