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Merck

I17451

Sigma-Aldrich

Isonicotinsäureamid

ReagentPlus®, 99%

Synonym(e):

Isonicotinamid

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25 G
CHF 41.40
100 G
CHF 71.30

About This Item

Empirische Formel (Hill-System):
C6H6N2O
CAS-Nummer:
Molekulargewicht:
122.12
Beilstein:
2173
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352100
PubChem Substanz-ID:
NACRES:
NA.22

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Produktlinie

ReagentPlus®

Assay

99%

mp (Schmelzpunkt)

155-157 °C (lit.)

SMILES String

NC(=O)c1ccncc1

InChI

1S/C6H6N2O/c7-6(9)5-1-3-8-4-2-5/h1-4H,(H2,7,9)

InChIKey

VFQXVTODMYMSMJ-UHFFFAOYSA-N

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Anwendung

Isonicotinamide (pyridine-4-carboxamide) can be used as a heterocyclic building block to synthesize:
  • 4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives as potential anti-tubercular agents.[1]
  • Organotin(IV) complexes of isonicotinamide via synthesis of phosphoramidate ligands for various biological activity studies.[2]
  • Bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as potent reactivators sarin.[2]

It can also be used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals.[3]

Rechtliche Hinweise

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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Die Dokumentenbibliothek aufrufen

New organotin (IV) complexes of nicotinamide, isonicotinamide and some of their novel phosphoric triamide derivatives: Syntheses, spectroscopic study and crystal structures
Gholivand K, et al.
Journal of Organometallic Chemistry, 695(9), 1383-1391 (2010)
QSAR, docking studies of 1, 3-thiazinan-3-yl isonicotinamide derivatives for antitubercular activity
Chitre TS, et al.
Computational Biology and Chemistry, 68, 211-218 (2017)
M Alba Sorolla et al.
Archives of biochemistry and biophysics, 510(1), 27-34 (2011-04-26)
Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG trinucleotide repeats, leading to an elongated polyglutamine sequence (polyQ) in the huntingtin protein. Misfolding of mutant polyQ proteins with expanded tracts results in aggregation, causing cytotoxicity. Oxidative stress
Yan Li et al.
European journal of pharmacology, 609(1-3), 13-18 (2009-03-17)
The phytoalexin resveratrol has been described to have chemopreventive and chemotherapeutic effects in several tumor models while its effects on osteosarcoma have not been extensively studied. Additionally, resveratrol is a potent activator of the Sirt1/Sir2 (silent information regulator 2) family
Srinu Tothadi et al.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 370(1969), 2900-2915 (2012-05-23)
The idea of a structural landscape is based on the fact that a large number of crystal structures can be associated with a particular organic molecule. Taken together, all these structures constitute the landscape. The landscape includes polymorphs, pseudopolymorphs and

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