914487

2-(Diphenylphosphanyl)benzamide

≥95%

• Synonym(e): 2-(Diphenylphosphino)-benzamide, DPBM, Phosphine for Staundinger reduction
• Empirische Formel (Hill-System): C₁₉H₁₆NOP
• CAS-Nummer: 343254-74-0
• Molekulargewicht: 305.31
• MDL-Nummer: MFCD32851675
• UNSPSC-Code: 12352200
• NACRES: NA.22
• Form: powder
• Assay: ≥95%

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Lagertemp.: −20°C
• SMILES String: P(c3c(cccc3)C(=O)N)(c2ccccc2)c1ccccc1
• InChI: 1S/C19H16NOP/c20-19(21)17-13-7-8-14-18(17)22(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,(H2,20,21)

Beschreibung

Allgemeine Beschreibung

It is recommended to make fresh stock stolutions prior to each use.

Anwendung

2-(Diphenylphosphanyl)benzamide (DPBM) is a phosphine useful in the Staudinger reduction in chemical biology and medicinal chemistry. Recently, DPBM was demonstrated to faciliate the reactivation of CRISPR/Cas9 functions by removing azidomethylnicotinyl (AMN) groups used to masked gRNA and inhibit CRISPR systems. AMN groups were originally added with the use of RNA probe NAI-N₃ (cat# 913812).

Sonstige Hinweise

Conditional control of RNA-guided nucleic acid cleavage and gene editing

Small-molecule control of protein function through Staudinger reduction

A FRET-based ratiometric two-photon fluorescent probe for dual-channel imaging of nitroxyl in living cells and tissues

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3