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Y0000281

Paroxetine hydrochloride hemihydrate

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

(3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride hemihydrate

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About This Item

Formule empirique (notation de Hill):
C19H20FNO3 · HCl · .5 H2O
Numéro CAS:
110429-35-1
Poids moléculaire :
374.83
Numéro MDL:
MFCD03658863
Code UNSPSC :
41116107
ID de substance PubChem :
329830897
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

paroxetine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

InChI

1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1

Clé InChI

QRQSGFFISBKLMZ-YHOFXEKLSA-N

Informations sur le gène

human ... SLC6A4(6532)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Paroxetine hydrochloride hemihydrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Y0000630

Paroxetine for system suitability, European Pharmacopoeia (EP) Reference Standard

1500218

Paroxetine hydrochloride, United States Pharmacopeia (USP) Reference Standard

Y0000578

Paroxetine hydrochloride (anhydrous), European Pharmacopoeia (EP) Reference Standard

Y0000581

Paroxetine hydrochloride (anhydrous) impurity H, European Pharmacopoeia (EP) Reference Standard

Y0000233

Paroxetine impurity A, European Pharmacopoeia (EP) Reference Standard

1500353

Paroxetine System Suitability Mixture A, United States Pharmacopeia (USP) Reference Standard

Y0000580

Paroxetine impurity E, European Pharmacopoeia (EP) Reference Standard

1500230

Paroxetine Related Compound B, United States Pharmacopeia (USP) Reference Standard

1500240

Paroxetine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1500251

Paroxetine Related Compound D, United States Pharmacopeia (USP) Reference Standard

1500273

Paroxetine Related Compound F, United States Pharmacopeia (USP) Reference Standard

1500284

Paroxetine Related Compound G, ~21% povidone, United States Pharmacopeia (USP) Reference Standard

Y0000579

Paroxetine hydrochloride (anhydrous) impurity C, European Pharmacopoeia (EP) Reference Standard

BP1024

Paroxetine hydrochloride hemihydrate, British Pharmacopoeia (BP) Reference Standard

BP746

Paroxetine impurity standard, British Pharmacopoeia (BP) Reference Standard

1500207

Paroxetine Related Compound E, United States Pharmacopeia (USP) Reference Standard

PHR3076

Paroxetine Related Compound C, pharmaceutical secondary standard, certified reference material

PHR3077

Paroxetine Related Compound F, pharmaceutical secondary standard, certified reference material

Pictogrammes

Exclamation markEnvironment
GHS07,GHS09

Mention d'avertissement

Warning

Mentions de danger

H302,H317,H319,H335,H410

Classification des risques

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Paroxetine maleate salt ≥98% (HPLC), solid

Sigma-Aldrich

P1372

Paroxetine maleate salt

Jeffrey S Berger et al.
Thrombosis and haemostasis, 109(1), 85-92 (2012-12-12)
The mechanism underlying a hyperreactive platelet phenotype remains unknown. Since serotonin has been shown to influence platelet biology and atherothrombosis, we sought to investigate the association of platelet serotonin transporter number, binding affinity, and uptake kinetics with platelet aggregation. A
N Byatt et al.
Acta psychiatrica Scandinavica, 127(2), 94-114 (2012-12-18)
Conflicting data have led to controversy regarding antidepressant use during pregnancy. The objectives of this study are to i) review the risks of untreated depression and anxiety, ii) review the literature on risks of exposure to antidepressants during pregnancy, iii)
Mohamed A El-Nabarawi et al.
International journal of pharmaceutics, 443(1-2), 307-317 (2013-01-23)
Paroxetine (PAX) is the most potent serotonin reuptake blocker antidepressant clinically available. This study is aimed to reduce the side effects accompanied with the initial high plasma concentration after oral administration of PAX and fluctuations in plasma levels and also
Zheng-Wu Peng et al.
Molecular and cellular biochemistry, 375(1-2), 105-113 (2013-01-08)
Paroxetine is a widely used antidepressant in clinic. Besides its role in inhibition of serotonin reuptake, resent studies indicate that the increase of hippocampal neurogenesis is also involved in its pharmacology. However, only limited data are available in this regard
Jennifer C Naylor et al.
Psychiatry research, 206(2-3), 318-320 (2013-01-02)
Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era
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