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SRP4363

Sigma-Aldrich

VEGF165 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonyme(s) :

Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VPF, Vascular Endothelial Growth Factor

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About This Item

Numéro MDL:
MFCD00286542
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in E. coli

Pureté

≥98% (HPLC)
≥98% (SDS-PAGE)

Forme

lyophilized

Puissance

1.0-7.0 ng/mL

Poids mol.

~38.2 kDa

Conditionnement

pkg of 10 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Impuretés

endotoxin, tested

Numéro d'accès NCBI

Q96KJ0

Numéro d'accès UniProt

P15692

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... VEGFA(7422)

Description générale

The gene VEGFA (vascular endothelial growth factor A) is a member of VEGF family of growth factors. The gene is localized to human chromosome 6p21.1. It contains eight exons interspaced by seven introns, spanning a length of 14 kb. The critical region of 2.36 kbp in human promoter lacks a consensus TATA box. However, it contains various consensus-binding sites for many transcriptional regulators.

Actions biochimiques/physiologiques

The gene VEGFA (vascular endothelial growth factor A) encodes a secreted mitogen that is found to participate in physiological and pathological angiogenesis. It serves as a growth factor for endothelial cells and functions in the formation of new blood vessels during embryonic development and adulthood. It binds to two tyrosine kinase receptors VEGFR1 and VEGFR2 and functions in angiogenesis and maintenance of vasculature.

Forme physique

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Genetic variants on chromosome 6p21.1 and 6p22.3 are associated with type 2 diabetes risk: a case-control study in Han Chinese.
Lu F
Journal of Human Genetics, 57, 320-325 (2012)
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors.
Lee S
The Journal of Cell Biology, 169, 681-691 (2005)
VEGFA is necessary for chondrocyte survival during bone development.
Zelzer E
Development, 131, 2161-2171 (2004)
Vivian Lehmann et al.
Biotechnology progress, 35(2), e2745-e2745 (2018-11-14)
The only cure available for Type 1 diabetes involves the transplantation of islets of Langerhans isolated from donor organs. However, success rates are relatively low. Disconnection from vasculature upon isolation and insufficient rate of revascularization upon transplantation are thought to
Vivian Lehmann et al.
Biotechnology progress, 35(2), e2745-e2745 (2018-11-14)
The only cure available for Type 1 diabetes involves the transplantation of islets of Langerhans isolated from donor organs. However, success rates are relatively low. Disconnection from vasculature upon isolation and insufficient rate of revascularization upon transplantation are thought to

Articles

VEGF Pathway

Read review on VEGF signaling pathway (Vascular endothelial growth factor (VEGF)/VEGF receptor) and find related products.

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