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I0161

Sigma-Aldrich

IWR-1

≥98% (HPLC), powder, Tankyrase1/2 inhibitor

Synonyme(s) :

4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-Benzamide, IWR1

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About This Item

Formule empirique (notation de Hill):
C25H19N3O3
Numéro CAS:
1127442-82-3
Poids moléculaire :
409.44
Code UNSPSC :
12352200
ID de substance PubChem :
329815302
Nomenclature NACRES :
NA.77

product name

IWR-1, ≥98% (HPLC)

Niveau de qualité

100

Pureté

≥98% (HPLC)

Couleur

white to beige

Solubilité

DMSO: 5 mg/mL, clear

Température de stockage

room temp

Chaîne SMILES 

O=C(Nc1cccc2cccnc12)c3ccc(cc3)N4C(=O)[C@@H]5[C@H]6C[C@H](C=C6)[C@@H]5C4=O

InChI

1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+

Clé InChI

ZGSXEXBYLJIOGF-ALFLXDJESA-N

Application

IWR-1 has been used as an antagonist for Wingless/Integrated (WNT) signaling pathway in human embryonic stem cells (hESCs), mice lewis lung carcinoma (LLC) and Sepia embryos.

Actions biochimiques/physiologiques

IWR-1 is a tankyrase inhibitor and is cytotoxic for cancer stem-like cells. It inhibits the in vivo progression of osteosarcoma. IWR-1 interacts with RNA polymerase II and is crucial for the formation of preinitiation complex.
The Wnt/b-catenin (‘canonical′) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b).

Caractéristiques et avantages

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Hirokazu Narita et al.
Scientific reports, 7(1), 13708-13708 (2017-10-24)
One of the major challenges in cell-based cardiac regenerative medicine is the in vitro construction of three-dimensional (3D) tissues consisting of induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) and a blood vascular network supplying nutrients and oxygen throughout the tissue after
Iwr1 protein is important for preinitiation complex formation by all three nuclear RNA polymerases in Saccharomyces cerevisiae
Esberg A, et al.
PLoS ONE, 6(6), e20829-e20829 (2011)
Fei Gao et al.
Cancer letters, 402, 177-189 (2017-06-13)
Akt1 is essential for the oncogenic transformation and tumor growth in various cancers. However, the precise role of Akt1 in advanced cancers is conflicting. Using a neuroendocrine TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model, we first show that the
Efficient differentiation of TBX18+/WT1+ epicardial-like cells from human pluripotent stem cells using small molecular compounds
Zhao J, et al.
Stem Cells and Development, 26(7), 528-540 (2017)
A serine in exon 11 determines the full transcriptional activity of TCF-4 in lung carcinoma cells
Yang B, et al.
Biochemical and biophysical research communications, 508(3), 675-681 (2019)
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