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V4512

Sigma-Aldrich

Vascular Endothelial Growth Factor from mouse

≥98% (SDS-PAGE), recombinant, expressed in E. coli, powder, suitable for cell culture

Synonyme(s) :

mVEGF, VEGF

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10 μG
577,00 $
50 μG
1 310,00 $

577,00 $

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10 μG
577,00 $
50 μG
1 310,00 $

About This Item

Numéro MDL:
MFCD01636149
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

577,00 $

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Nom du produit

Vascular Endothelial Growth Factor from mouse, VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture

Source biologique

mouse

Niveau de qualité

100

Produit recombinant

expressed in E. coli

Essai

≥98% (SDS-PAGE)

Forme

powder

Puissance

≤10 ng/mL

Qualité

endotoxin tested

Poids mol.

protein 39 kDa

Conditionnement

pkg of 10 μg
pkg of 50 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Technique(s)

cell culture | mammalian: suitable

Impuretés

<1 EU/μg

Numéro d'accès UniProt

Q00731

Température de stockage

−20°C

Informations sur le gène

mouse ... VEGFA(22339)

Catégories apparentées

Description générale

Vascular endothelial growth factor is also known as VPF, VEGF and MVCD1. It is secreted from endothelial cells and pericytes in response to hypoxia. It helps in inducing angiogenesis and microvascular hyperpermeability. VEGF levels are associated with vasculitic neuropathy and may be used to predict this disease.[1] It may also act as a marker in the development and progression of early precancerous lesions of oesophagus.[2]

Application

Vascular endothelial growth factor (VEGF) supports development of new blood vessels during embryonic development and after vascular injury.Vascular endothelial growth factor from mouse was used for ELISA[3] and in matrigel plugs (matrigel was supplemented with VEGF).[4]

Autres remarques

Homodimeric protein consisting of two 165 amino acid polypeptide chains of mouse VEGF.
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Forme physique

Lyophilized from a 0.2 μm filtered buffered solution.

Remarque sur l'analyse

The biological activity is measured by the ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
MKCW3097
MKCS8453
MKCQ7358
MKCP4955
MKCN4604

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Consulter la Bibliothèque de documents

Katsuhisa Tashiro et al.
Stem cells and development, 23(18), 2202-2210 (2013-12-19)
Vascular endothelial growth factor (VEGF) is reported to exhibit potent hematopoietic stem/progenitor cell (HSPC) mobilization activity. However, the detailed mechanisms of HSPC mobilization by VEGF have not been examined. In this study, we investigated the effect of VEGF on bone
Asieh Golozar et al.
European journal of cancer (Oxford, England : 1990), 50(16), 2855-2865 (2014-08-31)
Mechanisms involved in wound healing play some role in carcinogenesis in multiple organs, likely by creating a chronic inflammatory milieu. This study sought to assess the role of genetic markers in selected inflammation-related genes involved in wound healing (interleukin (IL)-1a
Benjamin B Bartelle et al.
Circulation research, 110(7), 938-947 (2012-03-01)
The formation and maintenance of a functional vasculature is essential for normal embryonic development, and genetic changes that affect the vasculature underlie pathogenesis in many human diseases. In vivo imaging in mouse models is required to understand the full complexity
Jafar Rezaie et al.
Journal of cellular biochemistry, 119(1), 524-535 (2017-06-14)
This experiment investigated the impact of serum from patients with type 2 diabetes mellitus on the angiogenic behavior of human mesenchymal stem cells in vitro. Changes in the level of Ang-1, Ang-2, cell migration, and trans-differentiation into pericytes and endothelial
Victor Manolov et al.
Clinical laboratory, 60(9), 1573-1577 (2014-10-09)
Vascular endothelial growth factor (VEGF) is secreted from endothelial cells and pericytes in response to hypoxia. It induces angiogenesis and microvascular hyperpermeability. We observe serum VEGF concentrations in some patients with vasculitic neuropathy. Plasma VEGF was measured using GenWay's human
Afficher tous les articles scientifiques apparentés

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VEGF-A stimulates blood vessel growth via endothelial cell proliferation, migration, and survival during embryonic development.

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