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SAB4200678

Sigma-Aldrich

Anti-Collagen Type I antibody, Mouse monoclonal

clone COL-1, purified from hybridoma cell culture

Synonyme(s) :

Monoclonal Anti-Collagen Type I antibody produced in mouse, OI4, alpha 1, alpha 2, collagen, type I

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About This Item

Code UNSPSC :
51111800
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

300

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

COL-1, monoclonal

Forme

buffered aqueous solution

Espèces réactives

pig, rat, human, deer, bovine

Concentration

~1 mg/mL

Technique(s)

ELISA: suitable
dot blot: suitable
immunoblotting: 1-2 μg/mL using recombinant human collagen, expressed in Nicotiana tabacum
immunohistochemistry: 3.5-7 μg/mL using frozen sections of human tonsil, human tongue or pig tongue

Isotype

IgG1

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... COL1A1(1277)

Description générale

Collagen type Iα1 (COL1A1) is encoded by the gene that is located on human chromosome 17q21.33. It is the most abundant extracellular matrix (ECM) protein in humans. Type 1 collagen is the major structural protein of bone, tendon, skin and cornea. The encoded protein is a heterotrimer consisting of two α1-chains and one α2-chain.
Collagens are present in the extracellular matrix and contains a chains which can differ in length.

Immunogène

bovine skin collagen type I

Application

Monoclonal Anti-Collagen Type I antibody produced in mouse has been used in immunohistochemical analysis and in vitro invasion assays.

Actions biochimiques/physiologiques

Collagen, type I (COL1A1) is an important component of the connective tissue matrix. It plays an important role in the growth and maintenance of organ and tissue integrity. This protein also participates in the process of tissue repair. COL1A1 is implicated in fibrosis.
Collagens are involved in structural roles. Additionally, they associate with various receptors and control cell proliferation, migration as well as differentiation.

Forme physique

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Paeoniflorin prevents postoperative peritoneal adhesion formation in an experimental rat model.
Gao Q, et al.
Oncotarget, 8(55), 93899-93899 (2017)
Overexpression of CXCR4 promotes invasion and migration of non?small cell lung cancer via EGFR and MMP?9.
Zuo J, et al.
Oncology Letters, 14(6), 7513-7521 (2017)
Bruna B Catinelli et al.
Scientific reports, 12(1), 7375-7375 (2022-05-06)
Gestational diabetes mellitus (GDM) plus rectus abdominis muscle (RAM) myopathy predicts long-term urinary incontinence (UI). Atrophic and stiff RAM are characteristics of diabetes-induced myopathy (DiM) in pregnant rats. This study aimed to determine whether swimming exercise (SE) has a therapeutic
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Respiratory research, 20(1), 87-87 (2019-05-11)
Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though the exact pathophysiological mechanisms of IPF remain unknown, TGF-β1 is thought to act as a main driver of
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