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495455

Sigma-Aldrich

Oligomycin

≥90% (mixture of A, B, and C isomers, HPLC), powder, Antibiotic, Calbiochem

Synonyme(s) :

Oligomycin

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10 MG
166,00 $

166,00 $

Disponible pour expédition le28 mars 2025Détails

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10 MG
166,00 $

About This Item

Formule empirique (notation de Hill) :
C45H74O11
Numéro CAS:
1404-19-9
Poids moléculaire :
791.06
Numéro MDL:
MFCD01779388
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

166,00 $

Disponible pour expédition le28 mars 2025Détails

Nom du produit

Oligomycin, A mixture of A, B, and C isomers.

Niveau de qualité

100

Essai

≥90% (mixture of A, B, and C isomers, HPLC)

Forme

powder

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze

Couleur

white

Conditions d'expédition

ambient

Température de stockage

−20°C

InChI

1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+

Clé InChI

MNULEGDCPYONBU-ZUSSGZTJSA-N

Description générale

A mixture of A, B, and C isomers. A macrolide antibiotic that inhibits membrane-bound mitochondrial ATP synthase, preventing phosphoryl group transfer. Induces apoptosis in cultured human lymphoblastoid and other mammalian cells.

Actions biochimiques/physiologiques

Cell permeable: no
Primary Target
Membrane-bound mitochondrial ATPase (F1)
Product does not compete with ATP.
Reversible: no

Avertissement

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 2 months at -20°C.

Autres remarques

Wolvetang, E.J., et al. 1994. FEBS Lett.339, 40.
Amoroso, S., et al. 1993. J. Pharmacol. Exp. Ther.264, 515.
Brustovetsky, N.N., et al. 1993. FEBS Lett.315, 233.
Nagamune, H., et al. 1993. Biochim. Biophys. Acta1141, 231.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Birte Plitzko et al.
Bio-protocol, 8(10), e2850-e2850 (2018-05-20)
Mammalian cells generate ATP by mitochondrial (oxidative phosphorylation) and non-mitochondrial (glycolysis) metabolism. Cancer cells are known to reprogram their metabolism using different strategies to meet energetic and anabolic needs ( Koppenol et al., 2011 ; Zheng, 2012). Additionally, each cancer
Thomas A Ryan et al.
The EMBO journal, 39(11), e102539-e102539 (2020-04-21)
Multiple mitochondrial quality control pathways exist to maintain the health of mitochondria and ensure cell homeostasis. Here, we investigate the role of the endosomal adaptor Tollip during the mitochondrial stress response and identify its interaction and colocalisation with the Parkinson's
Shuo Wan et al.
Frontiers in immunology, 12, 685984-685984 (2021-08-10)
Angiostrongylus cantonensis (AC), which parasitizes in the brain of the non-permissive host, such as mouse and human, is an etiologic agent of eosinophilic meningitis. Excretory-secretory (ES) products play an important role in the interaction between parasites and hosts' immune responses.
Chunxin Wang
Current protocols in cell biology, 86(1), e99-e99 (2019-12-27)
Mitophagy is a selective autophagy process that specifically removes damaged mitochondria via general autophagy. The two major recessive Parkinson's disease genes PINK1 and Parkin play essential roles in mitophagy initiation, increasing the interest in mitophagy in both basic and translational
Fumika Koyano et al.
EMBO reports, 20(12), e47728-e47728 (2019-10-12)
Ubiquitylation of outer mitochondrial membrane (OMM) proteins is closely related to the onset of familial Parkinson's disease. Typically, a reduction in the mitochondrial membrane potential results in Parkin-mediated ubiquitylation of OMM proteins, which are then targeted for proteasomal and mitophagic
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Questions

1–2 of 2 Questions  

  1. Could you provide information on the proportions or ratio of Oligomycin A, B, and C in this mixture? Additionally, are the proportions consistent between lots?

    1 answer

    1. The isomer ratio of product 495455 has not been determined. It is known that the total (A+B+C) is greater than or equal to 90 percent.

      Helpful?

  2. As for the oligomycin(495455),what solvent can I use to dissolve it in order to preserve it as long as possible?

    1 answer

    1. Oligomycin is soluble in DMSO at 50 mg/mL, in ethanol at 250 mg/mL, and in acetone at 50 mg/mL. The solution is stable for at least a week at 0-4 °C and for several months when stored frozen in aliquots at -20 °C.

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