362433

Diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate

96%

• Synonyme(s) : N-Methoxy-N-methyl-2-(diethyl phosphono)acetamide, N-Methoxy-N-methyl-phosphonoacetamide diethyl ester, Diethyl N-methoxy-N-methylphosphonoacetamide, Diethylphosphonoacetic acid N-methyl-N-methoxyamide
• Formule linéaire : CH₃ON(CH₃)COCH₂P(O)(OC₂H₅)₂
• Numéro CAS: 124931-12-0
• Poids moléculaire : 239.21
• Numéro Beilstein : 1875865
• Numéro MDL: MFCD00134233
• Code UNSPSC : 12352108
• ID de substance PubChem : 24862312
• Nomenclature NACRES : NA.22

Propriétés

• Pureté: 96%
• Forme: liquid
• Capacité de réaction: reaction type: C-C Bond Formation
• Indice de réfraction: n20/D 1.455 (lit.)
• Point d'ébullition: 90 °C/17 mmHg (lit.)
• Densité: 1.163 g/mL at 25 °C (lit.)
• Groupe fonctionnel: amine; phosphonate
• Chaîne SMILES: CCOP(=O)(CC(=O)N(C)OC)OCC
• InChI: 1S/C8H18NO5P/c1-5-13-15(11,14-6-2)7-8(10)9(3)12-4/h5-7H2,1-4H3
• Clé InChI: WYLRYBDGIILFIR-UHFFFAOYSA-N

Description

Application

Reactant for:

• Preparation of ring-expanded bryostatin analogs as antitumor agents
• Asymmertic synthesis of pinnatoxins A and G via diastereoselective Ireland-Claisen rearrangement, ring closing metathesis, and cyclization
• Rh2(II)-catalyzed nitro-group migration reactions
• Stereoselective synthesis of cyclohexanones via phase transfer catalyzed double addition reactions
• Stereoselective synthesis of (+)-polyrhacitide A via aldol reaction, Horner-Wardsworth-Emmons reaction, Evans acetal intramolecular oxa-Michael reaction and diastereoselective syn reduction reaction as the key steps
• Preparation of substituted furans via olefin cross-metathesis

Wittig carbonylating reagent.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 230.0 °F - closed cup
• Point d'éclair (°C): 110 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Gloves, type ABEK (EN14387) respirator filter