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C141

CGS-21680 hydrochloride hydrate

≥98% (HPLC), Adenosine A2A receptor agonist, solid

Synonym(s):

2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine hydrochloride hydrate

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5 MG

$355.00

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$658.00

25 MG

$1,620.00

$355.00

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About This Item

Empirical Formula (Hill Notation):
C23H29N7O6 · HCl · xH2O
CAS Number:
124182-57-6
Molecular Weight:
535.98 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24277698
NACRES:
NA.77
MDL number:
MFCD11045878
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated

Key Documents

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Product Name

CGS-21680 hydrochloride hydrate, solid

assay

≥98% (HPLC)

Quality Level

100

form

solid

storage condition

desiccated

color

white

solubility

DMSO: >10 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL

storage temp.

−20°C

SMILES string

O.Cl.CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(NCCc4ccc(CCC(O)=O)cc4)nc23

InChI

1S/C23H29N7O6.ClH.H2O/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32;;/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29);1H;1H2/t16-,17+,18-,22+;;/m0../s1

InChI key

VIRPCGAECNOLOO-VBQNEDDFSA-N

Gene Information

human ... ADORA2A(135), ADORA2B(136)

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1 of 4

This Item
PZ0136B2417E8284
CGS-21680 hydrochloride hydrate solid

Sigma-Aldrich

C141

CGS-21680 hydrochloride hydrate

CP-100263 dihydrochloride hydrate ≥97% (HPLC)

Sigma-Aldrich

PZ0136

CP-100263 dihydrochloride hydrate

Benzamil hydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

B2417

Benzamil hydrochloride hydrate

(E/Z)-Endoxifen Hydrochloride Hydrate ≥98% (HPLC)

Sigma-Aldrich

E8284

(E/Z)-Endoxifen Hydrochloride Hydrate

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >10 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL

solubility

H2O: ≥5 mg/mL

solubility

methanol: 10 mg/mL, DMSO: >20 mg/mL

solubility

DMSO: >10 mg/mL

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

desiccated

Biochem/physiol Actions

Adenosine receptor agonist, which possesses selectivity for A2 verses A1 receptors.

Disclaimer

Hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000161112
0000156800
0000148795
0000148794
0000148795

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Liu Yang et al.
Pediatric research (2022-02-28)
Reducing neuroinflammatory damage is an effective strategy for treating white-matter damage (WMD) in premature infants. Caffeine can ameliorate hypoxia-ischemia-induced brain WMD; however, its neuroprotective effect and mechanism against hypoxic-ischemic WMD remain unclear. We used 3-day-old Sprague-Dawley rats to establish a
J W Phillis
Brain research, 509(2), 328-330 (1990-02-19)
The A2 selective adenosine receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680) depressed the spontaneous, acetylcholine- and glutamate-evoked firing of rat cerebral sensorimotor cortical neurons. Iontophoretically applied CGS 21680 was equipotent with adenosine as a depressant and its actions were antagonized by 8-p-sulphophenyltheophylline
Seema Gulyani et al.
Experimental neurology, 215(2), 236-242 (2008-11-18)
Brain iron insufficiency has been implicated in several neurological disorders. The dopamine system is consistently altered in studies of iron deficiency in rodent models. Changes in striatal dopamine D(2) receptors are directly proportional to the degree of iron deficiency. In
M F Jarvis et al.
The Journal of pharmacology and experimental therapeutics, 251(3), 888-893 (1989-12-01)
Characterization of the adenosine A2 receptor has been limited due to the lack of available ligands which have high affinity and selectivity for this adenosine receptor subtype. In the present study, the binding of a highly A2-selective agonist radioligand, [3H]CGS
Wu Zheng et al.
Journal of neuroinflammation, 19(1), 52-52 (2022-02-20)
Multiple sclerosis (MS) is one of the most common autoimmune disorders characterized by the infiltration of immune cells into the brain and demyelination. The unwanted immunosuppressive side effect of therapeutically successful natalizumab led us to focus on the choroid plexus (CP)
View All Related Papers

Global Trade Item Number

SKUGTIN
C141-10MG04061832081403
C141-25MG04061832081410
C141-100MG04061832089638
C141-5MG04061833467510

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