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Documentos Principais

1005706

USP

Ácido acético

United States Pharmacopeia (USP) Reference Standard

Sinônimo(s):

Ácido acético glacial

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About This Item

Fórmula linear:
CH3CO2H
Número CAS:
Peso molecular:
60.05
Beilstein:
506007
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24
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grau

pharmaceutical primary standard

densidade de vapor

2.07 (vs air)

família API

glacial acetic acid

temperatura de autoignição

800 °F

Lim. expl.

16 %, 92 °F
4 %, 59 °F

fabricante/nome comercial

USP

técnica(s)

gas chromatography (GC): suitable

índice de refração

n20/D 1.371 (lit.)

p.e.

117-118 °C (lit.)

pf

16.2 °C (lit.)

densidade

1.04 g/mL at 25 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

cadeia de caracteres SMILES

[F2C(F2C)13F3C]C(O)=O

InChI

1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

chave InChI

QTBSBXVTEAMEQO-UHFFFAOYSA-N

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Descrição geral

Glacial acetic acid is the trivial name used to describe pure acetic acid in an anhydrous state. It is a clear and hygroscopic weak acid, typically available in concentrations ranging from 99.5% to 100%. The name "glacial" refers to the ice-like crystals that form at a temperature slightly below room temperature (16.6°C or 61.9°F), like the German term "Eisessig" (ice-vinegar). Despite being classified as a weak acid, glacial acetic acid is a corrosive poison that can cause harm or even be fatal when in contact with human tissue. Improper storage and handling of glacial acetic acid can pose inherent risks and may lead to patient injuries if not appropriately diluted.[1] Acetic acid/acetate is a common counter ion in peptide preparations.[2]
Glacial acetic acid USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Glacial acetic acid USP reference standard for use in specified quality tests and assays. It is also used to prepare standard solution by using liquid chromatography coupled to a UV detector according to the general chapter of United States Pharmacopeia (USP).[2] Based directly on official monographs published in the USP-NF, these highly characterized physical specimens are used in testing by pharmaceutical and related industries to help ensure the identity, strength, quality, and purity of peptide-based medicines.

Further information is available in the general chapter, 503- ACETIC ACID IN PEPTIDES, USP43-NF38 - 6741 of the USP (United States Pharmacopeia).

Outras notas

This product is part of the USP Biologics program.
Sales restrictions may apply.

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Pictogramas

FlameCorrosion

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

102.2 °F - closed cup

Ponto de fulgor (°C)

39 °C - closed cup


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ACETIC ACID IN PEPTIDES
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Glacial Acetic Acid Adverse Events: Case Reports and Review of the Literature
Doles W, et al.
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Acetic acid in peptides
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United States Pharmacopeia, 42(5), 6741-6741 (2017)
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Questions

1–2 of 2 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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