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47773

Supelco

Phylloquinone (K1)

analytical standard

Sinônimo(s):

Vitamin K1, 2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Vitamin K1(20)

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About This Item

Fórmula empírica (Notação de Hill):
C31H46O2
Número CAS:
84-80-0
Peso molecular:
450.70
Beilstein:
2568816
Número CE:
201-564-2
Número MDL:
MFCD00214063
Código UNSPSC:
12164500
ID de substância PubChem:
24871410
Preço e disponibilidade não estão disponíveis no momento.

grau

analytical standard

Formulário

oil

Certificado de análise (CofA)

current certificate can be downloaded

Características

standard type fat soluble vitamin

embalagem

ampule of 100 mg

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

índice de refração

n20/D 1.527 (lit.)

pf

−20 °C (lit.)

densidade

0.984 g/mL at 25 °C (lit.)

aplicação(ões)

food and beverages

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O

InChI

1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1

chave InChI

MBWXNTAXLNYFJB-NKFFZRIASA-N

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Categorias relacionadas

Descrição geral

Phylloquinone (K1) is a prenylated naphthoquinone. It is a fat soluble vitamin, produced by plants, green algae and some species of cyanobacteria. It functions as a coenzyme and is important for the synthesis of a number of proteins involved in blood clotting and bone metabolism.[1]

Aplicação

Phylloquinone (K1) may be used as an analytical reference standard for the quantification of the analyte in olive oil,[1] chard,[1] human plasma samples,[1] animal and plant food products[2] using reversed-phase high-performance liquid chromatography technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
LC26460V
LC25933V
LC25066V
LC24448V
LC24447V

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Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

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Phytomenadione European Pharmacopoeia (EP) Reference Standard

P1609000

Phytomenadione

Vitamin K1-4a,5,6,7,8,8a-13C6 ≥99 atom % 13C, ≥98% (CP)

Sigma-Aldrich

809888

Vitamin K1-4a,5,6,7,8,8a-13C6

Menadione (K3) analytical standard

Supelco

47775

Menadione (K3)

Vitamin K1 2,3-epoxide ≥98.0% (HPLC)

Sigma-Aldrich

19697

Vitamin K1 2,3-epoxide

(±)-α-Tocoferol analytical standard

Supelco

47783

(±)-α-Tocoferol

Piridoxina analytical standard

Supelco

47862

Piridoxina

Vitamin K2 (MK-4) solution 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-031

Vitamin K2 (MK-4) solution

Colecalciferol (D3) analytical standard

Supelco

47763

Colecalciferol (D3)

Application of a simplified HPLC assay for the determination of phylloquinone (vitamin K1) in animal and plant food items
Jakob E and Elmadfa I
Food Chemistry, 56(1), 87-91 (1996)
Determination of vitamin K1 content in olive oil, chard and human plasma by RP-HPLC method with UV?Vis detection
Otles S and Cagindi O
Food Chemistry, 100(3), 1220-1222 (2007)
Xi Gu et al.
Plant physiology, 185(4), 1443-1456 (2021-04-02)
Nonphotosynthetic holoparasites exploit flexible targeting of phylloquinone biosynthesis to facilitate plasma membrane redox signaling. Phylloquinone is a lipophilic naphthoquinone found predominantly in chloroplasts and best known for its function in photosystem I electron transport and disulfide bridge formation of photosystem
Ellen C M Cranenburg et al.
Kidney international, 82(5), 605-610 (2012-06-01)
Vitamin K is essential for the activity of γ-carboxyglutamate (Gla)-proteins including matrix Gla28 protein and osteocalcin; an inhibitor of vascular calcification and a bone matrix protein, respectively. Insufficient vitamin K intake leads to the production of non-carboxylated, inactive proteins and
Rogier Caluwé et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(7), 1385-1390 (2013-11-29)
Haemodialysis patients suffer from accelerated vascular calcification. The vitamin K-dependent matrix Gla protein (MGP) is one of the most powerful inhibitors of vascular calcification. Haemodialysis patients have high levels of the inactive form of MGP (desphosphorylated-uncarboxylated-MGP, dp-uc-MGP) and may benefit
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Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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