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Methapyrilene HCl

analytical standard

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About This Item

Número CAS:
Número CE:
Número MDL:
Código UNSPSC:
12000000
ID de substância PubChem:

grau

analytical standard

Certificado de análise (CofA)

current certificate can be downloaded

embalagem

ampule of 1000 mg

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

clinical testing

formato

neat

temperatura de armazenamento

2-30°C

cadeia de caracteres SMILES

CN(C)CCN(CC1=CC=CS1)C2=NC=CC=C2.Cl

InChI

1S/C14H19N3S.ClH/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14;/h3-8,11H,9-10,12H2,1-2H3;1H

chave InChI

BONORRGKLJBGRV-UHFFFAOYSA-N

Informações sobre genes

human ... HRH1(3269)

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Descrição geral

Methapyrilene is an H1-receptor antihistamine that is known to cause periportal hepatic necrosis following acute high dose administration to the rat subjects in in vitro studies carried out for the identification of mutagens and/or carcinogens.

Aplicação

Methapyrilene HCl may be used as an analytical reference standard for the determination of the analyte in animal feed, human urine and wastewater by high-performance liquid chromatography (HPLC) and gas chromatography (GC) techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogramas

Skull and crossbones

Palavra indicadora

Danger

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation.
Ratra GS, et al.
Chemico-Biological Interactions, 129(3), 279-295 (2000)
Trace analysis of the antihistamines methapyrilene hydrochloride, pyrilamine maleate and triprolidine hydrochloride monohydrate in animal feed, human urine and wastewater by high-performance liquid chromatography and gas chromatography with nitrogen-phosphorus detection.
Thompson Jr HC and Holder CL
Journal of Chromatography A, 283(3), 251-264 (1984)

Artigos

Analysis of 20 pharmaceutical compounds in calf serum using Supel™ Swift HLB SPE cartridge for cleanup and LC-MS determination and another commercially available HLB cartridge for comparison.

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