The recommended guard column for the 15024AST column is 15100AST, which is an Astec® CHIROBIOTIC® V2 Chiral HPLC Guard Column Cartridge with a 5 μm particle size and dimensions of 2 cm length and 4 mm inner diameter. Additionally, the recommended holder is 21150AST, a Supelguard™ Guard Cartridge Holder Stand-Alone (Swivel-type) designed for use with Supelguard cartridges, with dimensions of 2 cm length and 2 to 4.6 mm inner diameter.
15024AST
Astec® CHIROBIOTIC® V2 Chiral (5 μm) HPLC Columns
L × I.D. 25 cm × 4.6 mm, HPLC Column
Sinônimo(s):
Chirobiotic V2 TM=["Astec"] Chromatography Column
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About This Item
Código UNSPSC:
41115700
eCl@ss:
32110501
NACRES:
SB.52
C × D.I.:
25 cm × 4.6 mm
tamanho de partícula:
5 μm
Grupo ativo da matriz:
vancomycin phase
tamanho de poro:
200 Å
Matriz:
High-purity silica gel particle platform
fully porous particle
fully porous particle
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Nome do produto
Astec® CHIROBIOTIC® V2 Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Materiais
stainless steel column
Nível de qualidade
Agency
suitable for USP L88
descrição
HPLC column
linha de produto
Astec®
embalagem
pkg of 1 ea
fabricante/nome comercial
Astec®
Parâmetros
0-45 °C temperature
241 bar pressure (3500 psi)
técnica(s)
HPLC: suitable
LC/MS: suitable
C × D.I.
25 cm × 4.6 mm
Matriz
High-purity silica gel particle platform
fully porous particle
Grupo ativo da matriz
vancomycin phase
tamanho de partícula
5 μm
tamanho de poro
200 Å
Faixa de pH operacional
3.5-7.0
técnica de separação
chiral
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Descrição geral
Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC® V in the polar ionic mode. The CHIROBIOTIC® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
- Bonded phase: Vancomycin
- Operating pH range: 3.5 - 7.0
- Particle diameter: 5, 10 or 16 μm
- Pore size: 100 Å (CHIROBIOTIC® V) or 200 Å (CHIROBIOTIC® V2)
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
Aplicação
- Chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography-tandem mass spectrometry: This study utilized the CHIROBIOTIC® V2 column to achieve chiral separation of dextromethorphan and levomethorphan in human hair, highlighting the column′s application in forensic toxicology for precise enantiomeric analysis (Ji et al., 2022).
- Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma: This research demonstrates the application of CHIROBIOTIC® V2 for pharmacokinetic studies in rats, establishing a method for enantioselective determination that can be crucial for drug development and therapeutic monitoring (Zhang et al., 2016).
- New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase: The use of CHIROBIOTIC® V2 column in developing a new HPLC method for the separation of warfarin enantiomers underscores its utility in clinical analysis and therapeutic drug monitoring, showing its broad applicability in biomedical research (Malakova et al., 2009).
Informações legais
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
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Conteúdo relacionado
Astec CHIROBIOTIC™ V2 Chiral HPLC Columns offered by Sigma-Aldrich. The polar organic and the polar ionic modes have become increasingly popular largely because of their ideal compatibility with MS detection and preparative LC.
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What guard column should be used for the 15024AST column?
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