WH0003845M1

Anti-KRAS Antibody

mouse monoclonal, 3B10-2F2

• Sinônimo(s): KRAS Antibody - Monoclonal Anti-KRAS antibody produced in mouse, Kras Antibody, Anti-CKRAS, Anti-KIRAS, Anti-KRAS1, Anti-KRAS2, Anti-KRAS2A, Anti-KRAS2B, Anti-KRAS4A, Anti-KRAS4B, Anti-RASK2, Anti-v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
• Número MDL: MFCD00239650
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• Nome do produto: Monoclonal Anti-KRAS antibody produced in mouse, clone 3B10-2F2, purified immunoglobulin, buffered aqueous solution
• fonte biológica: mouse
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 3B10-2F2, monoclonal
• Formulário: buffered aqueous solution
• reatividade de espécies: human
• técnica(s): ELISA: suitable; capture ELISA: suitable; immunofluorescence: suitable; western blot: 1-5 μg/mL
• Isotipo: IgG1κ
• nº de adesão GenBank: BC013572
• nº de adesão UniProt: P01116
• aplicação(ões): research pathology
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... KRAS(3845)

Descrição

Descrição geral

Kirsten rat sarcoma viral oncogene homologue (KRAS) is an oncogene that is mapped to human chromosome 12p12.1. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. The gene codes for a member of the small GTPase superfamily.

Imunogênio

KRAS (AAH13572, 1 a.a. ~ 188 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKKSKTKCVIM

Aplicação

Monoclonal Anti-KRAS antibody produced in mouse has been used in immunoprecipitation, immunofluorescence, western blotting,[1] indirect enzyme linked immunosorbent assay (ELISA).

Ações bioquímicas/fisiológicas

Kirsten rat sarcoma viral oncogene homologue (KRAS) is a key protein of the Ras signaling pathways. It facilitates the invasion and metastasis of tumors. Gain-of-function mutations in the gene leads to the development of variety of tumors, including pancreatic, biliary tract and colon tumors. This mutation is rarely observed in gastric cancer.

forma física

Solution in phosphate buffered saline, pH 7.4

Informações legais

GenBank is a registered trademark of United States Department of Health and Human Services

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)