V9505
Monoclonal Anti-Vitamin B12 antibody produced in mouse
clone CD-29, ascites fluid
Sinônimo(s):
Anti-Cyanocobalamin
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0.5 ML
R$ 5.912,00
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0.5 ML
R$ 5.912,00
About This Item
Produtos recomendados
fonte biológica
mouse
conjugado
unconjugated
forma do anticorpo
ascites fluid
tipo de produto de anticorpo
primary antibodies
clone
CD-29, monoclonal
contém
15 mM sodium azide
técnica(s)
indirect ELISA: 1:5,000
Isotipo
IgG1
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Descrição geral
Monoclonal Anti-Vitamin B12 antibody reacts with vitamin B12, as well as with vitamin B12-KLH and vitamin B12-BSA conjugates in human plasma and serum.
Vitamin B12 or cobalamin is a water-soluble vitamin. It is the largest and most complex among all the vitamins. Vitamin B12 is naturally found in animal foods, meat, milk, egg, fish and shellfish.
Aplicação
Monoclonal Anti-Vitamin (B12) antibody has been used in enzyme linked immunosorbent assay (ELISA)
Monoclonal Anti-Vitamin B12 antibody produced in mouse has also been used in immunocytochemistry.
Ações bioquímicas/fisiológicas
Vitamin B12 serves as a cofactor for methionine synthase and L-methylmalonyl−coenzyme A mutase. It is essential for the maintenance and development of CNS. Vitamin B12 deficiency leads to megaloblastic anemia and neuropathy.
Vitamin B12 regulates genomic stability. While increased levels of vitamin B12 have been associated with hepatic and hematological disorders; cobalamin deficiency has been associated with orthostatic hypotension and depression . The antibody also detects coenzyme B12 and methyl vitamin B12, but does not associate with BSA, folic acid, and 5-methyltetrahyrofolic acid.
Vitamin B12 and folic acid can be used for treating disorders of central nervous system (CNS) development, mood, and cognitive decline, including some dementias.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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A A M Ermens et al.
Clinical biochemistry, 36(8), 585-590 (2003-11-26)
Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Not surprisingly, a
Vitamin B12, folic acid, and the nervous system
Reynolds E
Lancet Neurology, 5(11), 949-960 (2006)
Allan Moore et al.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 14(2), 67-71 (2004-04-20)
Orthostatic hypotension (OH) and vitamin B12 deficiency are common disorders in older people. Several case series have reported an association between vitamin B12 deficiency and OH. The effect of vitamin B12 replacement on this dysfunction has not been studied. We
Alec Coppen et al.
Journal of psychopharmacology (Oxford, England), 19(1), 59-65 (2005-01-27)
We review the findings in major depression of a low plasma and particularly red cell folate, but also of low vitamin B12 status. Both low folate and low vitamin B12 status have been found in studies of depressive patients, and
Henrik Birn et al.
American journal of physiology. Renal physiology, 282(3), F408-F416 (2002-02-08)
Megalin has previously been shown to bind and mediate endocytosis of transcobalamin (TC)-B(12). However, the physiological significance of this has not been established, and other TC-B(12) binding proteins have been suggested to mediate renal uptake of this vitamin complex. The
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