Pular para o conteúdo
Merck
Todas as fotos(4)

Documentos Principais

Visualizar Toda a Documentação

V5765

Sigma-Aldrich

Vascular Endothelial Growth Factor 165 human

≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

Sinônimo(s):

Vascular Endothelial Growth Factor 165

Faça loginpara ver os preços organizacionais e de contrato

Selecione um tamanho

10 μG
R$ 1.228,00
50 μG
R$ 4.406,00

R$ 1.228,00

Check Cart for Availability
Todas as fotos(4)

Selecione um tamanho

Alterar visualização
10 μG
R$ 1.228,00
50 μG
R$ 4.406,00

About This Item

Código UNSPSC:
12352202
NACRES:
NA.77

R$ 1.228,00

Check Cart for Availability

Nome do produto

VEGF165, recombinant, expressed in HEK 293 cells, suitable for cell culture

fonte biológica

human

Nível de qualidade

200

recombinante

expressed in HEK 293 cells

descrição

Vascular Endothelial Growth Factor 165 human

Ensaio

≥95% (SDS-PAGE)

Formulário

lyophilized powder

potência

<10 ng/mL ED50

qualidade

endotoxin tested

peso molecular

dimer 42 kDa (glycosylated)

embalagem

pkg of 10 μg
pkg of 50 μg

técnica(s)

cell culture | mammalian: suitable

Impurezas

<0.075 EU/μg

cor

white

solubilidade

water: soluble

nº de adesão UniProt

P15692

temperatura de armazenamento

−20°C

Informações sobre genes

human ... VEGFA(7422)

Categorias relacionadas

Descrição geral

VEGF165 is expressed in human HEK 293 cells as a glycosylated homodimer with an apparent molecular mass of 45 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Ações bioquímicas/fisiológicas

VEGF165 belongs to the PDGF/VEGF growth factor family characterized by the presence of eight conserved cysteine residues and a cystine knot structure.[1] VEGF is secreted by the majority of tumor cells and initiates angiogenesis by activating endothelial cells of existing blood vessels and promoting their migration.[2]
VEGF has also been implicated in correlation with poor prognosis in breast cancer.[2]
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).[3][4]

Nota de análise

The specific activity was determined by the dose-dependent stimulation of the proliferation of HUVEC cells (human umbilical vein endothelial cells).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
0000233619
0000166601
0000166601
0000233619
126M4794V

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Lee M Ellis
Hematology/oncology clinics of North America, 18(5), 1007-1021 (2004-10-12)
This article focuses on the preclinical evidence for activation of the epidermal growth factor receptor (EGFR) in promoting angiogenesis and the efficacy of anti-EGFR agents in inhibiting angiogenesis and tumor growth.
Cheng Wang et al.
Nature communications, 12(1), 2616-2616 (2021-05-12)
FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-membrane protein, and mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs). This study aims to determine the contributions of FUNDC1-mediated MAMs to angiogenesis in vitro and in vivo. In cultured
Xiaoqiang Tang
Cancer letters, 332(1), 3-10 (2013-01-26)
Breast cancer development largely depends upon the essential contributions from the tumor microenvironment, where several inflammatory cell populations (e.g. macrophages) orchestrate breast cancer development. The majority of tumor-associated macrophages (TAMs) exhibit alternatively activated M2 properties, produce abundant anti-inflammatory factors and
C J Robinson et al.
Journal of cell science, 114(Pt 5), 853-865 (2001-02-22)
Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role in both angiogenesis and vasculogenesis. VEGF is a promising target for therapeutic intervention in
A O Afuwape et al.
Histology and histopathology, 17(3), 961-972 (2002-08-10)
The expansion of the synovial lining of joints in rheumatoid arthritis (RA), and the subsequent invasion by the pannus of underlying cartilage and bone, necessitates an increase in the vascular supply to the synovium, to cope with the increased requirement
Exibir todos os documentos relacionados

Artigos

VEGF Pathway

Read review on VEGF signaling pathway (Vascular endothelial growth factor (VEGF)/VEGF receptor) and find related products.

Questions

Reviews

No rating value

Active Filters

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica