About This Item
Fórmula empírica (Notação de Hill):
C206H338N62O64
Número CAS:
Peso molecular:
4707.26
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.32
Produtos recomendados
fonte biológica
rat
Nível de qualidade
Ensaio
≥97% (HPLC)
Formulário
powder
técnica(s)
western blot: suitable
solubilidade
1% acetic acid: >1 mg/mL, clear, colorless
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
rat ... Ucn(29151)
Amino Acid Sequence
Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
Aplicação
Urocortin rat can be used for western blotting. The product can also be used for studying that whether CRF receptor type 2 (CRF2) and its high-affinity ligand, urocortin 1 (Ucn1) can mediate sex-specific cellular stress responses by using corticotropin-releasing factor receptor 2-deficient (Crhr2-/- ) and wild-type (WT) mice.
Ações bioquímicas/fisiológicas
Binds to CRF receptor types 1, 2α, and 2β.
Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.
Urocortin is a CRF-related neuropeptide that binds to CRF receptor types 1α, 2α and 2β. It possesses appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.
Nota de preparo
Urocortin rat dissolves in 1% acetic acid at 1 mg/ml to yield a clear, colorless solution.
Outras notas
Lyophilized from 0.1% TFA in H2O
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Escolha uma das versões mais recentes:
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Urocortin interaction with corticotropin-releasing factor (CRF) binding protein (CRF-BP): a novel mechanism for elevating "free' CRF levels in human brain.
Behan DP
Brain Research, 725 (1996)
Eric Kubat et al.
Molecular medicine (Cambridge, Mass.), 19, 212-222 (2013-07-10)
Although females suffer twice as much as males from stress-related disorders, sex-specific participating and pathogenic cellular stress mechanisms remain uncharacterized. Using corticotropin-releasing factor receptor 2-deficient (Crhr2-/-) and wild-type (WT) mice, we show that CRF receptor type 2 (CRF2) and its
A De Luca et al.
European journal of histochemistry : EJH, 53(3), 167-176 (2009-10-30)
Urocortin (UCN) is a 40 aminoacid peptide which belongs to corticotropin-releasing factor (CRF) family. This family of peptides stimulates the secretion of proopiomelanocortin (POMC)-derived peptides, adrenocorticotropic hormone (ACTH), beta-endorphin and melanocyte-stimulating hormone (MSH) in the pituitary gland. In the present
Nina C Donner et al.
Progress in neuro-psychopharmacology & biological psychiatry, 96, 109730-109730 (2019-08-16)
The bed nucleus of the stria terminalis (BNST) is a nodal structure in neural circuits controlling anxiety-related defensive behavioral responses. It contains neurons expressing the stress- and anxiety-related neuropeptide corticotropin-releasing hormone (Crh) as well as Crh receptors. Repeated daily subthreshold
M Spina et al.
Science (New York, N.Y.), 273(5281), 1561-1564 (1996-09-13)
The neuropeptide corticotropin-releasing factor (CRF) is well known to act on the central nervous system in ways that mimic stress and result in decreases in exploration, increases in sympathetic activity, decreases in parasympathetic outflow, and decreases in appetitive behavior. Urocortin
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica