Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos

T8575

Sigma-Aldrich

Anti-Tryptophan Hydroxylase antibody produced in sheep

affinity isolated antibody, buffered aqueous glycerol solution

Sinônimo(s):

Anti-TPH

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Número MDL:
MFCD00282500
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

sheep

Nível de qualidade

200

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous glycerol solution

uso

sufficient for 10 blots

reatividade de espécies

mammals, human

técnica(s)

western blot: 1:1,000 using human dorsal raphe nucleus

nº de adesão UniProt

P17752

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

human ... TPH1(7166)
mouse ... Tph1(21990)
rat ... Tph1(24848)

Categorias relacionadas

Descrição geral

The tryptophan hydroxylase 1 (TPH1) gene spanning 29kbp with 11 exons is mapped to human chromosome 11p15.3-p14. TPH1, is a 444 amino acid protein expressed in the gut, spleen, thymus and also in the pineal gland and the pituitary.
Tryptophan Hydroxylase (TPH) is a member of the aromatic amino acid hydroxylases (AAAH) family.

Imunogênio

recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE.

Aplicação

Anti-Tryptophan Hydroxylase antibody produced in sheep has been used in:
  • immunocytochemistry
  • immunohistochemistry
  • immunofluorescence
  • immunoperoxidase staining

Ações bioquímicas/fisiológicas

The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan, which is a precursor to the neurotransmitter serotonin. Variation in the gene expression affects prefrontal cortex activation during response inhibition. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders. The encoded protein plays a vital role in regulation of cardiovascular function.

forma física

Solution in 150 mM NaCl, 10 mM HEPES, pH 7.5, 100 μg per mL BSA, and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Ferramenta de seleção de produtos.

recomendado

Nº do produto
Descrição
Preços

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Matthew W Hale et al.
Journal of chemical neuroanatomy, 41(4), 219-226 (2011-06-07)
Tryptophan hydroxylase is the rate-limiting enzyme in the biosynthesis of serotonin (5-hydroxytryptamine; 5-HT). Two isoforms of tryptophan hydroxylase, derived from different genes, tph1 and tph2, have been identified. The tph1 isoform is expressed in peripheral tissues, whereas tph2 is brain
Tryptophan hydroxylase 1 gene polymorphisms alter prefrontal cortex activation during response inhibition.
Ruocco AC
Neuropsychology, 30, 18-27 (2016)
R C Drugan et al.
Neuroscience, 253, 221-234 (2013-09-04)
Prior adverse experience alters behavioral responses to subsequent stressors. For example, exposure to a brief swim increases immobility in a subsequent swim test 24h later. In order to determine if qualitative differences (e.g. 19°C versus 25°C) in an initial stressor
Rachel A Walker et al.
The European journal of neuroscience, 51(3), 866-880 (2019-08-04)
Aversive, positive prediction error (+PE) provides a mechanism to update and increase future fear to uncertain threat predictors. The ventrolateral periaqueductal grey (vlPAG) has been offered as a neural locus for +PE computation. Yet, a causal demonstration of vlPAG +PE
Mahsa Moaddab et al.
Scientific reports, 10(1), 18035-18035 (2020-10-24)
Early adolescent adversity increases adult risk for anxiety disorders. The ventrolateral periaqueductal gray (vlPAG) and neighboring dorsal raphe (DR) are integral to threat prediction, and are responsive to acute stressors. Here, we tested the hypothesis that early adolescent adversity reshapes
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica